Altered sympathetic thermoregulation in patients with hypothalamic dysfunction following resection of suprasellar tumors

Autonomic Neuroscience : Basic & Clinical
Tadashi WatanabeJun Yoshida

Abstract

In patients with suprasellar tumors, both the tumor and its surgical resection may produce hypothalamic dysfunction including thermoregulatory disturbances. We quantitated skin sympathetic nerve activity using microneurography in eight patients with hypothalamic dysfunction following resection. Skin sympathetic nerve activity, skin blood flow (by laser Doppler flowmetry), sweating, blood pressure, and pulse rate were monitored during changes of core (tympanic) temperature in the patients and seven healthy controls. Core temperature was decreased by 0.3 degrees C and increased by 0.5 degrees C relative to baseline using a cooling/heating blanket. The increase in sympathetic nerve activity in response to cooling did not differ between controls and patients (41.0+/-13.1 vs. 38.1+/-7.7 bursts [min degrees C](-1)), but an increase upon heating in controls (45.1+/-5.4 bursts [min degrees C](-1)) was absent in the patients (-26.0+/-17.5 bursts [(min degrees C](-1)). Skin blood flow during heating increased significantly in controls but not in patients (35.6+/-14.6 vs. 15.8+/-5.8 ml [min 100 g tissue degrees C](-1)). The patients thus showed impaired heat loss during body temperature elevation. Microneurography proved to be a sensitive...Continue Reading

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Citations

Mar 14, 2012·Saudi Journal of Anaesthesia·Enrique J Carrero, Neus Fàbregas
Jun 12, 2013·Physiological Reports·Matthew D MullerChester A Ray
Oct 25, 2016·The Journal of Dermatology·Takichi MunetsuguHiroo Yokozeki
Sep 30, 2020·Medicine·Chan-Hyuk LeeHyun Goo Kang
Aug 15, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tadaaki ManoShinobu Toma

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