Altered temporal features of intrinsic connectivity networks in boys with combined type of attention deficit hyperactivity disorder

European Journal of Radiology
Xun-Heng Wang, Lihua Li

Abstract

Investigating the altered temporal features within and between intrinsic connectivity networks (ICNs) for boys with attention-deficit/hyperactivity disorder (ADHD); and analyzing the relationships between altered temporal features within ICNs and behavior scores. A cohort of boys with combined type of ADHD and a cohort of age-matched healthy boys were recruited from ADHD-200 Consortium. All resting-state fMRI datasets were preprocessed and normalized into standard brain space. Using general linear regression, 20 ICNs were taken as spatial templates to analyze the time-courses of ICNs for each subject. Amplitude of low frequency fluctuations (ALFFs) were computed as univariate temporal features within ICNs. Pearson correlation coefficients and node strengths were computed as bivariate temporal features between ICNs. Additional correlation analysis was performed between temporal features of ICNs and behavior scores. ADHD exhibited more activated network-wise ALFF than normal controls in attention and default mode-related network. Enhanced functional connectivities between ICNs were found in ADHD. The network-wise ALFF within ICNs might influence the functional connectivity between ICNs. The temporal pattern within posterior defau...Continue Reading

References

Mar 2, 2005·Biological Psychiatry·Manzar AshtariBabak A Ardekani
Jun 14, 2005·Biological Psychiatry·Joseph Biederman
Dec 7, 2007·Brain & Development·Lixia TianYufeng Wang
Jan 15, 2008·Journal of Neuroscience Methods·Lucina Q UddinMichael P Milham
Nov 19, 2008·The American Journal of Psychiatry·Anqi QiuStewart H Mostofsky
Sep 29, 2009·NeuroImage·Xi-Nian ZuoMichael P Milham
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Jun 16, 2011·Journal of Cognitive Neuroscience·Angela R LairdPeter T Fox
Sep 1, 2011·European Archives of Psychiatry and Clinical Neuroscience·Andreas KonradGeorg Winterer
Oct 20, 2011·NeuroImage·Danielle S BassettKelvin O Lim
May 21, 2013·European Journal of Radiology·Xunheng WangZuhong Lu
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Mar 29, 2014·Human Brain Mapping·Chandra SripadaMichael Angstadt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.