Altered thermal grill response and paradoxical heat sensations after topical capsaicin application

Pain
Ellen Lund SchaldemoseNanna B Finnerup

Abstract

The thermal grill illusion, where interlaced warm and cold bars cause an unusual burning sensation, and paradoxical heat sensations (PHS), where cold is perceived as warm when alternating warm and cold, are examples of a complex integration of thermal sensations. Here, we investigated the effect of sensitization of heat-sensitive neurons on cold and warm integration. We examined thermal thresholds, PHS, and warm, cold, and pain sensations to alternating cold (10°C) and warm (40°C) bars (the thermal grill [TG]) in the primary area (application site) after topical application with capsaicin and vehicle control (ethanol) on the volar forearms in randomized order in 80 healthy participants. As expected, capsaicin induced heat allodynia and hyperalgesia and decreased cold and cold pain sensation. In addition, we found that after capsaicin application, the TG caused less pain and burning than the 40°C bars alone in contrast to the control side where the TG caused more pain and burning, consistent with the thermal grill illusion. In both situations, the pain intensity during the TG correlated inversely with both cold and warm pain thresholds but not with detection thresholds. Paradoxical heat sensation was only seen in 3 participants ...Continue Reading

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Citations

Jul 19, 2016·Behavioural Brain Research·Michael K BoettgerHans-Georg Schaible
Oct 17, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lise VentzelNanna B Finnerup
Jan 13, 2017·Scientific Reports·Catherine R JutzelerJohn L K Kramer
Jan 31, 2020·Frontiers in Human Neuroscience·Lukas D LindeJohn L K Kramer
Sep 10, 2020·Journal of the Peripheral Nervous System : JPNS·Kristine BennedsgaardNanna B Finnerup
Jun 26, 2020·Physiological Reviews·Nanna Brix FinnerupTroels Staehelin Jensen
Aug 18, 2020·Neurobiology of Disease·Julia ForstenpointnerDavid Borsook
Aug 28, 2021·Journal of Clinical Medicine·Dong Ah Shin, Min Cheol Chang

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