Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4

European Journal of Immunology
Daniella A Mendes-da-CruzW Savino

Abstract

We previously showed migration disturbances in the thymus during experimental infection with Trypanosoma cruzi, the causative agent of Chagas disease. These changes were related to the enhanced expression of extracellular matrix ligands and receptors, leading to the escape of immature cells to the periphery. Here, we analyzed the expression and role of selected chemokines (CXCL12 and CCL4) and their receptors (CXCR4 and CCR5) in regulating thymocyte migration in conjunction with extracellular matrix during acute T. cruzi infection. We found increased chemokine deposition in the thymus of infected mice when compared to controls, accompanied by enhanced co-localization with fibronectin as well as up-regulated surface expression of CXCR4 and CCR5 in thymocytes. We also noticed altered thymocyte migration towards the chemokines analyzed. Such an enhancement was even more prominent when fibronectin was added as a haptotatic stimulus in combination with a given chemokine. Our findings suggest that thymocyte migration results from a combined action of chemokines and extracellular matrix (ECM), which can be altered during pathological conditions such as T. cruzi infection, and may be at the origin of the changes in the T cell repertoir...Continue Reading

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Citations

Jul 23, 2013·Trends in Immunology·Cláudio Nunes-AlvesMargarida Correia-Neves
Nov 21, 2007·The British Journal of Nutrition·Wilson SavinoSuse Dayse Silva-Barbosa
Nov 23, 2011·Development, Growth & Differentiation·Toshiyasu Goto, Makoto Asashima
Sep 29, 2011·Neuroimmunomodulation·Ana Rosa PérezOscar Bottasso
Jul 8, 2009·PLoS Neglected Tropical Diseases·Juliana de MeisWilson Savino
Jul 19, 2006·PLoS Pathogens·Wilson Savino
Nov 26, 2013·Memórias do Instituto Oswaldo Cruz·Désio Aurélio Farias-de-OliveiraWilson Savino
Jun 8, 2012·Molecular Immunology·Galia RamírezArturo Ferreira
Oct 7, 2015·Nature Reviews. Endocrinology·Wilson SavinoMireille Dardenne
Jun 26, 2007·Scandinavian Journal of Immunology·M M Ribeiro-CarvalhoW Savino
Apr 21, 2012·Journal of Parasitology Research·Juliana de MeisWilson Savino
Sep 24, 2010·The Proceedings of the Nutrition Society·Wilson Savino, Mireille Dardenne
Sep 13, 2019·Cellular Microbiology·Mariana De NizJoana Tavares
Apr 19, 2016·Immunological Reviews·Mohammed S ChaudhryMarcel R M van den Brink
Sep 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annette B VogelOliver Planz
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniella A Mendes-da-CruzWilson Savino
Nov 20, 2021·Frontiers in Cellular and Infection Microbiology·Luiz Ricardo BerbertAna Rosa Pérez
Mar 2, 2010·Immunobiology·Patrícia R A NagibLiana Verinaud

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