PMID: 6399857Jan 1, 1984Paper

Altered tissue distribution of amphotericin B by liposomal encapsulation: comparison of normal mice to mice infected with Candida albicans

Cancer Drug Delivery
G Lopez-BeresteinR Mehta

Abstract

Recently, it has been observed that encapsulation of Amphotericin B (Amp-B) into multilamellar vesicles (liposomes) decreases the toxicity associated with the administration of Amp-B, while maintaining its antifungal efficacy. In this study, the tissue concentrations of Amp-B in normal mice and in mice infected with Candida albicans were examined. Amp-B concentrations in various tissues were quantitated by high-performance liquid chromatography. Liposomal encapsulation improved the delivery of Amp-B to the liver, spleen, lung, and kidney in both normal and infected mice. Furthermore, after injection of the encapsulated drug, Amp-B was demonstrable in brain tissue of infected animals at potentially therapeutic concentrations. None was demonstrable in the brains of normal animals or animals injected with free Amp-B. The results suggest that capillary endothelial damage and phagocytic cell uptake may contribute to an enhanced liposome delivery of Amp-B to those organs most frequently infected with fungi.

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Citations

Jan 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K M Wasan, G Lopez-Berestein
Jun 19, 1987·Pharmaceutisch Weekblad. Scientific Edition·F Emmen, G Storm
Jan 1, 1985·Cancer Drug Delivery·G Lopez-BeresteinK Mehta
Sep 23, 2000·The Pediatric Infectious Disease Journal·R L Chapman, R G Faix
Feb 1, 1992·Scandinavian Journal of Immunology·A TibellB Sundberg
Dec 1, 1987·Antimicrobial Agents and Chemotherapy·R T MehtaG Lopez-Berestein
May 1, 1987·Antimicrobial Agents and Chemotherapy·G Lopez-Berestein
Jun 1, 1988·Antimicrobial Agents and Chemotherapy·P R WydeV Knight
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·K M WasanG Lopez-Berestein
Mar 18, 2000·Antimicrobial Agents and Chemotherapy·A H GrollT J Walsh
Jan 12, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·A H GrollT J Walsh
Dec 8, 2000·Pharmaceutical Development and Technology·K K Chakraborty, S R Naik
Jan 1, 1994·Journal of Drug Targeting·K M Wasan, G Lopez-Berestein
Aug 15, 1994·Annals of the New York Academy of Sciences·K M Wasan, G Lopez-Berestein
Aug 4, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Maroof AlamOwais Mohammad
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Oct 1, 1990·Regulatory Toxicology and Pharmacology : RTP·E M VoisinP C Hoyle
Dec 5, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Akira WatanabeKatsuhiko Kamei
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Christoph M. Tang, Ian C. J. W. Bowler
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Sep 26, 1997·Antimicrobial Agents and Chemotherapy·K M WasanR L Thies
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·K M WasanG Lopez-Berestein

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