PMID: 8948475Nov 13, 1996Paper

Altered tissue-specific opsonic activities and opsono-recognition of liposomes in tumour-bearing rats

Biochimica Et Biophysica Acta
S M Moghimi, H M Patel

Abstract

Reticuloendothelial phagocytic and serum opsonic activity was evaluated at terminal stages of tumour growth in rats transplanted subcutaneously with chondrosarcoma in an attempt to evaluate the role of opsonic protein(s) in governing liposome recognition and clearance by the macrophage system. The liver of the tumour-bearing animals manifested a decline in the uptake of multilamellar vesicles composed of egg phosphatidylcholine: cholesterol: dicetyl phosphate (mole ratio 7:2:1) from the blood when compared to healthy animals. In contrast, an increase in splenic clearance of liposomes was encountered in tumour-bearing rats. Studies with isolated liver non-parenchymal cells suggested that liposome recognition in both health and at terminal stages of cancer growth is influenced by a serum opsonin, which can be precipitated by 35-50% ammonium sulphate, as well as the concentration of calcium levels in serum. Serum of healthy animals equally enhanced liposome recognition by the hepatic macrophages of both normal and tumour-bearing rats. In contrast, both cell populations manifested poor liposome recognition in the presence of serum pooled from tumour-bearing animals and the results were comparable to the corresponding liposome-cell ...Continue Reading

References

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Sep 18, 1989·Biochimica Et Biophysica Acta·S M Moghimi, H M Patel
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Jun 5, 1996·Journal of the National Cancer Institute·S M Moghimi, J C Murray

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Citations

Feb 20, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hilary ShmeedaAlberto Gabizon
Oct 21, 2009·Journal of Microencapsulation·Pawan K AngraMartin J D'Souza
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·A H van der VeenT L ten Hagen

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