Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study

Frontiers in Neuroscience
Xiaofeng LinNingyi Jiang

Abstract

Tinnitus is a prevalent hearing disorder, which could have a devastating impact on a patient's life. Functional studies have revealed connectivity pattern changes in the tinnitus brains that suggested a change of network dynamics as well as topological organization. However, no studies have yet provided evidence for the topological network changes in the gray matter. In this research, we aim to use the graph-theoretical approach to investigate the changes of topology in the tinnitus brain using structural MRI data, which could provide insights into the underlying anatomical basis for the neural mechanism in generating phantom sounds. We collected 3D MRI images on 46 bilateral tinnitus patients and 46 age and gender-matched healthy controls. Brain networks were constructed with correlation matrices of the cortical thickness and subcortical volumes of 80 cortical/subcortical regions of interests. Global network properties were analyzed using local and global efficiency, clustering coefficient, and small-world coefficient, and regional network properties were evaluated using the betweenness coefficient for hub connectivity, and interregional correlations for edge properties. Between-group differences in cortical thickness and subc...Continue Reading

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Citations

Mar 16, 2021·Frontiers in Neuroscience·Xiaoning ShengUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 28, 2021·EBioMedicine·By Royce E Clifford
May 3, 2021·Brain Structure & Function·Pia BrinkmannMichael Schwartze
Jul 29, 2021·Human Genetics·Ely Cheikh BoussatyRoyce E Clifford

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Software Mentioned

GAT
Eloc
Sigma
Eglob
Linux
GAT ( Graph Analysis Toolbox )
FreeSurfer

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