Altered urinary polyamine patterns of cancer patients under acupuncture therapy

Amino Acids
M J PaikK-R Kim

Abstract

The reduction of elevated polyamine (PA) levels in biological fluids of cancer patients were known to be correlated with remission following diverse therapeutic treatments. In this study, altered urinary PA levels from three different cancer cases were monitored at different intervals during the long-term weekday acupuncture treatments. Nine urinary PA levels from 16 normal and three cancer patients with different types were measured by gas chromatography-mass spectrometry in selected ion monitoring mode as N-ethoxycarbonyl-N-pentafluoropropionyl derivatives. Their levels measured at three follow-up stages for each patient were then normalized to the corresponding normal group means and plotted into star symbol patterns. Large alterations of PA levels were observed for each patient. Each normalized concentration displayed elevation of the PA levels in multiples (0.0-57.7) of the respective normal mean values. The normalized PA values were transformed into distorted star patterns which were characteristic of each follow-up stage and of cancer type.

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Citations

Aug 7, 2013·Scientific Reports·Kai LiuXi Zhang
Dec 23, 2014·Sensors and Actuators. B, Chemical·James T Fletcher, Brent S Bruck
Jun 21, 2016·Analytical Chemistry·Akhtar Hussain MalikParameswar Krishnan Iyer
Mar 21, 2017·Probiotics and Antimicrobial Proteins·Cesar Antonio Irecta-NájeraAnne Santerre
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Hyonna KangByung Je Cho
Jan 21, 2011·Journal of the American Chemical Society·Masato IkedaItaru Hamachi

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