Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure

The Journal of Endocrinology
P W F HadokeC J Kenyon

Abstract

Excessive exposure to glucocorticoids during gestation reduces birth weight and induces permanent hypertension in adulthood. The mechanisms underlying this programmed elevation of blood pressure have not been established. We hypothesised that prenatal glucocorticoid exposure may lead to vascular dysfunction in adulthood. Pregnant rats received dexamethasone (Dex) (100 microg/kg, s.c.) or vehicle (control) daily throughout pregnancy. Blood pressure was elevated (students t-test, unpaired; P < 0.05) in adult female offspring (aged 12-16 weeks) of Dex-treated mothers (148.0 +/- 3.6 mmHg, n=10) compared with the control group (138.0 +/- 2.5 mmHg, n=8). Vascular responsiveness in aortae and mesenteric arteries was differentially affected by prenatal Dex: aortae were less responsive to angiotensin II, whereas mesenteric arteries were more responsive to norepinephrine, vasopressin and potassium (mesenteric arteries respond poorly to angiotensin II in vitro). Acetylcholine-mediated, endothelium-dependent relaxation was similar in both groups. Prenatal exposure to Dex had no effect on blood pressure or aldosterone response to acute (15 min, i.v.) infusion of angiotensin II (75 ng/kg per min). In contrast, chronic (2-week, s.c.) infusion...Continue Reading

Citations

Aug 10, 2006·Cellular and Molecular Neurobiology·Wentsworth B KennedyLincoln P Edwards
Sep 26, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junchang GuanZhice Xu
Jun 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hossam A ShaltoutDavid B Averill
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniela GrigoreBarbara T Alexander
Feb 7, 2008·The Journal of Endocrinology·David O'ReganMegan C Holmes
Jan 1, 2008·Future Cardiology·Norma B OjedaBarbara T Alexander
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Batbayar Khulan, Amanda J Drake
May 28, 2008·Gender Medicine·Daniela GrigoreBarbara T Alexander
May 28, 2015·Pediatric Cardiology·Joana MorgadoConstança Coelho
May 14, 2016·World Journal of Clinical Pediatrics·Serafina PerroneGiuseppe Buonocore
Mar 19, 2008·Hypertension·Gergö A MolnarAnette Fiebeler
Mar 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Andrew J KingGregory D Fink
Jan 31, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lara M DurrantWilliam J Pearce
Feb 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Samantha L RogersJeremy W Tomlinson
Jul 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill M GoldsteinRobert J Handa
Jul 26, 2018·Neuroscience and Biobehavioral Reviews·Julia J MüllerMatthias Schwab

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