PMID: 6977442Feb 1, 1982Paper

Altered vascular responsiveness in isolated perfused lungs from aging rats

Experimental Lung Research
A TuckerN Migally

Abstract

Systemic vascular hyporesponsiveness has been well documented in aged rats, but a similar decreased vasoreactivity of the pulmonary vasculature has not been reported. Isolated lungs from young (3-5 months) and middle-aged (12-14 months) rats were perfused with whole blood and challenged alternately with alveolar hypoxia, angiotensin II, and 5-hydroxytryptamine. Hypoxic pulmonary vasoconstriction was less in the aging rats during both 5-min and 10-min hypoxic exposures. Likewise, log-dose response curves for angiotensin II and 5-hydroxytryptamine were right-shifted in the aging rats, indicating decreased responsiveness to the vasoactive agents. Since the vascular responses to all three vasoconstrictors were lower in the older animals, a generalized pulmonary vascular hyporeactivity with advancing age is suggested.

References

Jan 1, 1975·Mechanisms of Ageing and Development·E Ericsson, L Lundholm
Oct 1, 1978·British Journal of Pharmacology·S Hayashi, N Toda
Jan 1, 1977·Experimental Gerontology·J A FuentesN H Neff
Mar 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·A TuckerJ T Reeves
Apr 1, 1976·Circulation Research·A P Fishman
Mar 1, 1974·Circulation Research·N K HollenbergJ P Merrill
Feb 1, 1970·Circulation Research·J H FleischB B Brodie
Jan 1, 1980·Pharmacology & Therapeutics·J H Fleisch

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Citations

Sep 1, 1986·Acta Physiologica Scandinavica·F KröllA Ryrfeldt
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward

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