Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles.

Epilepsia
Jeffrey D RileyJack J Lin

Abstract

Diffusion tensor imaging (DTI) studies have reported substantial white matter abnormalities in patients with temporal lobe epilepsy (TLE). However, limited data exist regarding the extent of white matter tract abnormalities, cognitive effects of these abnormalities, and relationship to clinical factors. The current study examined these issues in subjects with chronic TLE. DTI data were obtained in 12 TLE subjects and 10 age-matched healthy controls. Voxel-wise statistical analysis of fractional anisotropy (FA) was carried out using tract-based spatial statistics (TBSS). White matter integrity was correlated with cognitive performance and epilepsy-related clinical parameters. Subjects with TLE, as compared to healthy controls, demonstrated four clusters of reduced FA, in anterior temporal lobe, mesial temporal lobe, and cerebellum ipsilateral, as well as frontoparietal lobe contralateral to the side of seizure onset. Mean FA was positively correlated with delayed memory, in anterior temporal lobe; and immediate memory, in mesial temporal lobe. Lower FA values in the posterior region of corpus callosum were related to earlier age of seizure onset. TLE is associated with widespread disturbances in white matter tracts and these cha...Continue Reading

References

Jan 1, 1992·Acta neurochirurgica·U Ebeling, D von Cramon
Nov 1, 1985·Annals of Neurology·R J Tusa, L G Ungerleider
Sep 1, 1995·Brain Research. Brain Research Reviews·H J Markowitsch
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·R SchlösserJ D Brodie
May 13, 1998·Brain : a Journal of Neurology·J D Schmahmann, J C Sherman
Nov 3, 1998·Brain : a Journal of Neurology·B LevineD T Stuss
Nov 11, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C Randolph
Nov 25, 1998·Brain : a Journal of Neurology·M Gomez-Beldarrain, J C Garcia-Monco
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·C RandolphT N Chase
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Nov 27, 1999·Developmental Medicine and Child Neurology·J SchoenfeldB Hermann
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Nov 5, 2002·Magnetic Resonance Imaging·Konstantinos ArfanakisMary E Meyerand
Jun 18, 2003·Seizure : the Journal of the British Epilepsy Association·Felipe Antonio De MarcosFernano Cendes
Oct 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·B GottwaldH M Mehdorn
Jan 18, 2005·NeuroImage·Geoffrey J M ParkerMatthew A Lambon Ralph
Jul 30, 2005·Epilepsy & Behavior : E&B·Bruce P HermannMichael Seidenberg
Aug 16, 2005·Biophysical Journal·Pabitra N Sen, Peter J Basser
Sep 6, 2005·Brain : a Journal of Neurology·Marco Catani, Dominic H ffytche
Apr 22, 2006·Cerebral Cortex·Thomas R BarrickChris A Clark
Oct 14, 2006·Hippocampus·Asaf GilboaMorris Moscovitch
Aug 31, 2007·Brain : a Journal of Neurology·Bernd WeberChristoph Helmstaedter
Oct 3, 2008·Epilepsy Research·Jack J LinSteven C Cramer
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann
Jun 1, 1948·The Journal of Applied Psychology·J TIFFIN, E J ASHER
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dorothee SaurCornelius Weiller
Mar 18, 2009·NeuroImage·Jan-Christoph Schoene-BakeBernd Weber
Jun 11, 2009·AJNR. American Journal of Neuroradiology·M E AhmadiE Halgren

❮ Previous
Next ❯

Citations

Oct 22, 2011·Journal of the International Neuropsychological Society : JINS·N Erkut KucukboyaciC R McDonald
Feb 10, 2011·Nature Reviews. Neurology·Brian BellBruce Hermann
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Björn H SchottEmrah Düzel
Mar 15, 2011·Brain : a Journal of Neurology·Duygu TosunBruce Hermann
Nov 1, 2011·Cerebral Cortex·Maarten J VaessenWalter H Backes
Jul 16, 2011·Epilepsia·Donald W Gross
Apr 5, 2012·Epilepsia·Kevin DabbsBruce Hermann
Jun 14, 2012·Epilepsia·Firas FahoumJean Gotman
Aug 15, 2012·Epilepsia·Hilde M H BraakmanPaul A M Hofman
Jun 19, 2014·BMC Neurology·Hila GoldbergRobert Zivadinov
Dec 3, 2014·Neuroimaging Clinics of North America·Umair J Chaudhary, John S Duncan
May 8, 2013·Brain : a Journal of Neurology·Rebecca J Von Der HeideIngrid R Olson
Feb 5, 2015·The Cerebellum·Yael LeitnerHeidi M Feldman
Aug 13, 2015·Clinical Neurology and Neurosurgery·Kang Min ParkSung Eun Kim
Apr 26, 2013·Epilepsia·Gavin P WinstonJohn S Duncan
Oct 12, 2013·Acta Neurologica Scandinavica·H M H BraakmanW H Backes
Jul 26, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zhenyin LiuShijun Qiu
May 17, 2015·Brain Research·Seongtaek LeeLawrence W Ver Hoef
Nov 3, 2012·Epilepsy & Behavior : E&B·Laura AddisRochelle Caplan
Nov 2, 2013·NeuroImage. Clinical·J StrettonJ S Duncan
Sep 20, 2012·Epilepsy Research·Connie SungBruce P Hermann
Jan 2, 2014·Epilepsy Research·Elysa WidjajaMary Lou Smith
Sep 15, 2011·NeuroImage·Susann BoretiusChristine Stadelmann
Jun 12, 2013·Epilepsy & Behavior : E&B·Sabine HellwigLudger Tebartz van Elst
Jul 20, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Hai LiStephen T Wong
Jul 13, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Carrie R McDonaldVicente J Iragui
Jul 30, 2014·Frontiers in Aging Neuroscience·Ryan P D AlexanderDonald William Gross

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