Altering Genomic Integrity: Heavy Metal Exposure Promotes Transposable Element-Mediated Damage

Biological Trace Element Research
Maria E MoralesAstrid M Roy-Engel

Abstract

Maintenance of genomic integrity is critical for cellular homeostasis and survival. The active transposable elements (TEs) composed primarily of three mobile element lineages LINE-1, Alu, and SVA comprise approximately 30% of the mass of the human genome. For the past 2 decades, studies have shown that TEs significantly contribute to genetic instability and that TE-caused damages are associated with genetic diseases and cancer. Different environmental exposures, including several heavy metals, influence how TEs interact with its host genome increasing their negative impact. This mini-review provides some basic knowledge on TEs, their contribution to disease, and an overview of the current knowledge on how heavy metals influence TE-mediated damage.

References

Dec 30, 1991·Science·S L MathiasA Gabriel
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G A MitchellD Valle
Sep 1, 1989·Molecular & General Genetics : MGG·V A Bradshaw, K McEntee
Mar 1, 1985·Cell·J D BoekeG R Fink
Aug 11, 1983·Nature·J H Rogers, K R Willison
Nov 1, 1995·Nature Medicine·M Nyström-LahtiB Vogelstein
Nov 29, 1996·Cell·J V MoranH H Kazazian
Aug 1, 1997·Trends in Genetics : TIG·J A YoderT H Bestor
Jan 7, 1998·Molecular and Cellular Biology·B ElliottM Jasin
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P StroutM A Caligiuri
Dec 22, 1998·Nature·P Capy
Jun 25, 1999·Molecular Genetics and Metabolism·P L Deininger, M A Batzer
Mar 4, 2000·Cancer Investigation·M Jasin
Jun 1, 2000·Journal of Inorganic Biochemistry·M P Waalkes
Jan 3, 2001·Molecular and Cellular Biology·S L Martin, F D Bushman
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Mar 10, 2001·Mutation Research·L Staleva Staleva, P Venkov
Dec 18, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·K D DeviP Grover
Jun 8, 2002·Toxicology Letters·H CangulM Costa
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A HartwigA Bürkle
Jul 5, 2002·Genome Research·Rotem SorekDan Graur
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Angeline S AndrewJoshua W Hamilton
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brook BrouhaHaig H Kazazian
Aug 5, 2003·Nature Genetics·Marie DewannieuxThierry Heidmann
Nov 25, 2003·American Journal of Human Genetics·Eric M OstertagHaig H Kazazian
Dec 31, 2003·Trends in Genetics : TIG·Jenny Kreahling, Brenton R Graveley
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K DanadeviP Grover
May 26, 2004·Environmental Health Perspectives·Daniel R McNeillDavid M Wilson
Aug 20, 2004·Nature·Déborah Bourc'his, Timothy H Bestor
Jun 1, 1950·Proceedings of the National Academy of Sciences of the United States of America·B McCLINTOCK
Jan 7, 2005·Photodermatology, Photoimmunology & Photomedicine·Gautam BanerjeeGovindarajan Raman
Jan 29, 2005·Journal of Microbiological Methods·Margarita PeshevaPencho Venkov
Oct 27, 2005·Journal of Molecular Biology·Mohammed El-SawyPrescott L Deininger
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
Dec 31, 2005·EXS·Troy R Durham, Elizabeth T Snow
Feb 24, 2006·Journal of Molecular Biology·Stephen L GasiorPrescott L Deininger
Mar 2, 2006·Nucleic Acids Research·Evan A FarkashEline T Luning Prak

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Citations

Mar 5, 2016·Mobile Genetic Elements·Travis B WhitePrescott L Deininger
Aug 16, 2016·Mobile DNA·John L Goodier
Oct 26, 2016·Mobile Genetic Elements·Astrid M Roy-Engel
Dec 14, 2018·Genome Research·Caroline EsnaultHenry L Levin
Mar 8, 2020·Environmental and Molecular Mutagenesis·Brunella Del Re, Gianfranco Giorgi
Nov 5, 2019·Frontiers in Genetics·Sára Sándor, Enikő Kubinyi

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