Altering surface characteristics of polypropylene mesh via sodium hydroxide treatment

Journal of Biomedical Materials Research. Part a
Shawn RegisSankha Bhowmick

Abstract

Incisional hernias represent a serious and common complication following laparotomy. The use of synthetic (e.g. polypropylene) meshes to aid repair of these hernias has considerably reduced recurrence rates. While polypropylene is biocompatible and has a long successful clinical history in treating hernias and preventing reherniation, this material may suffer some limitations, particularly in challenging patients at risk of wound failure due to, for example, an exaggerated inflammation reaction, delayed wound healing, and infection. Surface modification of the polypropylene mesh without sacrificing its mechanical properties, critical for hernia repair, represents one way to begin to address these clinical complications. Our hypothesis is treatment of a proprietary polypropylene mesh with sodium hydroxide (NaOH) will increase in vitro NIH/3T3 cell attachment, predictive of earlier and improved cell colonization and tissue integration of polypropylene materials. Our goal is to achieve this altered surface functionality via enhanced removal of chemicals/oils used during material synthesis without compromising the mechanical properties of the mesh. We found that NaOH treatment does not appear to compromise the mechanical strength o...Continue Reading

References

Oct 16, 2003·The Journal of Surgical Research·Brent D MatthewsB Todd Heniford
May 6, 2006·Ultramicroscopy·Zachary Burton, Bharat Bhushan
Sep 29, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Michael G Franz
Sep 18, 2007·Biomolecular Engineering·C CholletM C Durrieu
May 7, 2008·Biomedical Materials·Yan-Peng Jiao, Fu-Zhai Cui
May 30, 2009·Acta Biomaterialia·Vignesh MuthuvijayanRandy S Lewis

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Citations

Dec 29, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·C G Pereira-lucenaM M Linhares

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