Mar 7, 1995

Alternans and period-doubling bifurcations in atrioventricular nodal conduction

Journal of Theoretical Biology
J SunJ Billette


A theoretical model, formulated as a finite difference equation is proposed for rate-dependent conduction properties of the atrioventricular (AV) node. The AV nodal conduction time, which is defined as the time interval from the atrial activation to the activation of the bundle of His, depends on the history of activation of the node. The theoretical model, which incorporates physiological concepts of recovery, facilitation and fatigue, accurately predicts a variety of experimentally observed complex rhythms of nodal conduction. In particular, alternans rhythms, in which there is an alternation in conduction time from beat to beat, are associated with period-doubling bifurcations in the theoretical model.

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Mentioned in this Paper

Theoretical Model
Structure of Atrioventricular Node
NODAL gene
Bundle of His
Heart Atrium
Cardiac Conduction
Heart Alternation
Electrocardiographic Recorders

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