PMID: 11915979Mar 28, 2002Paper

Alternans in QRS amplitude during ventricular tachycardia

Pacing and Clinical Electrophysiology : PACE
Philippe Maury, Jacques Metzger

Abstract

Although the value of T wave alternans as an index of electrical instability has been extensively investigated, little is known about QRS alternans during VT. Intracardiac electrograms of 111 episodes of spontaneous monomorphic regular VT retrieved from implantable defibrillators in 25 patients were retrospectively selected. Three beat series, representing the total amplitudes and amplitudes from baseline to summit and from baseline to lower point of 16 or 32 successive QRS complexes before deliverance of electrical therapy were generated for each episode. Spectral analysis was then performed using the fast Fourier transform. VT was considered as alternans if the magnitude of the spectral power at the 0.5-cycle/beat frequency was greater than the mean +/- 3 SD of the noise in at least one of the three spectral curves. QRS alternans was present in 23 (20%) of 111 episodes and in 9 (36%) of 25 patients. Alternans was not related to the VT cycle length, QRS duration, QRS amplitude, signal amplification, nor to clinical variables. Alternans was more frequently detected in unipolar configuration and when a higher number of complexes was included in analysis. Failure of antitachycardia pacing was more frequent in case of alternans VT...Continue Reading

Citations

Sep 29, 2015·Pacing and Clinical Electrophysiology : PACE·S Serge BaroldRoland X Stroobandt
Jan 26, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Frederic E Van HeuverswynS Serge Barold
Oct 31, 2006·Journal of Molecular and Cellular Cardiology·Andrea A DomenighettiThierry Pedrazzini
Dec 18, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Benjamin K A ThomsonRobert M Lindsay

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