Alternaria aerosol during a bovine respiratory syncytial virus infection alters the severity of subsequent re-infection and enhances IgE production

Comparative Immunology, Microbiology and Infectious Diseases
W V KalinaL J Gershwin

Abstract

Previous studies with cattle and rodent models have shown that bovine and human RSV infections influence the immune response to inhaled allergen. In the present study, we extended these observations to examine the effect of fungal allergen Alternaria alternata aerosol exposure (prior to and during BRSV infection) on the immune response and clinical outcome of a secondary BRSV infection. Calves were either Alternaria (Alt)/mock Alt (mAlt) and BRSV/mBRSV exposed. Exposures began on day -6 and continued every other day until day 6 post infection. A second set of aerosols/infection began on day 103 and continued as before. Clinical outcome during infections was measured in each group. IgG1, IgA, and IgE responses to Alternaria were measured in serum or bronchiolar alveolar lavage fluid (BALF). Cytokine responses, including IL-4, were also measured. Alternaria did not influence primary infection; however, the Alt/BRSV group had less disease than mAlt/BRSV group (median clinical score 8 vs 476.5; p<or=0.01) after secondary infection. Exposure to Alternaria facilitated IgE antibody production in BRSV infected calves. IgE responses to Alternaria were higher in Alt/BRSV than Alt/mBRSV animals on day 10 (mean baseline fold increase 1.97 ...Continue Reading

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Citations

Apr 12, 2013·Clinical Reviews in Allergy & Immunology·Andrea T BorchersLaurel J Gershwin
Mar 4, 2008·American Journal of Veterinary Research·Laurel J GershwinRichard F Larson
Nov 26, 2014·Annual Review of Animal Biosciences·Laurel J Gershwin
Jan 26, 2008·Animal Health Research Reviews·Laurel J Gershwin
Sep 16, 2021·The Journal of Infectious Diseases·Joseph McGinleyUNKNOWN REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators

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