Alternate-day oral therapy with TS-1 for advanced gastric cancer

International Journal of Clinical Oncology
Wataru AraiTetsuhiko Shirasaka

Abstract

TS-1 (1M tegafur-0.4M 5-chloro-2,4-dihydroxypyrimidine-1M potassium oxonate) has a high single-agent response rate, of more than 40%, for gastric cancer; however, the recommended regimen of 4 weeks of administration interrupted by 2 weeks of drug withdrawal frequently causes adverse effects. The alternate-day dosage of pyrimidine fluoride anticancer drugs could reduce their adverse effects without compromising their effects. We attempted an alternate-day therapy with TS-1 aiming at the avoidance of adverse effects and significantly longer duration of administration. We observed patients for clinical effects and adverse effects under alternate-day dosage of TS-1, and determined blood 5-fluorouracil (FU) levels. The judgment of clinical effects was based on the New Guidelines to Evaluate the Response to Treatment in Solid Tumors (RECIST), whereas the evaluation of adverse effects was based on the National Cancer Institute NCI-common toxicity criteria (CTC). In 72 (78%) of 92 patients, the TS-1 regimen was converted to the alternate-day dosage because of adverse effects. Twenty patients were treated with the alternate-day dosage regimen from the start because of the fear of adverse effects. The alternate-day dosage was clinically ...Continue Reading

Citations

Aug 21, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shigeru TatebeMasahide Ikeguchi
Feb 18, 2006·Annals of Surgical Oncology·Chikara KunisakiHiroshi Shimada
Mar 3, 2010·International Journal of Clinical Oncology·Kazuya SakumaTetsuhiko Shirasaka
Sep 11, 2014·World Journal of Gastroenterology : WJG·Jian YangChun-Ni Xu
May 16, 2019·International Journal of Clinical Oncology·Toshikazu MoriwakiIchinosuke Hyodo
May 10, 2019·Japanese Journal of Clinical Oncology·Akihiko MiyanagaUNKNOWN Tokyo Cooperative Oncology Group
Jul 2, 2017·International Journal of Clinical Oncology·Hiroaki TanakaKosei Hirakawa
Jun 22, 2021·The Journal of Veterinary Medical Science·Yuta NishiyamaKensuke Orito

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