Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Cell Carcinoma Progression

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Samira A BrooksW Kimryn Rathmell

Abstract

Clear cell renal cell carcinoma (ccRCC) has recently been redefined as a highly heterogeneous disease. In addition to genetic heterogeneity, the tumor displays risk variability for developing metastatic disease, therefore underscoring the urgent need for tissue-based prognostic strategies applicable to the clinical setting. We have recently employed the novel PET/magnetic resonance (MR) image modality to enrich our understanding of how tumor heterogeneity can relate to gene expression and tumor biology to assist in defining individualized treatment plans. ccRCC patients underwent PET/MR imaging, and these images subsequently used to identify areas of varied intensity for sampling. Samples from 8 patients were subjected to histologic, immunohistochemical, and microarray analysis. Tumor subsamples displayed a range of heterogeneity for common features of hypoxia-inducible factor expression and microvessel density, as well as for features closely linked to metabolic processes, such as GLUT1 and FBP1. In addition, gene signatures linked with disease risk (ccA and ccB) also demonstrated variable heterogeneity, with most tumors displaying a dominant panel of features across the sampled regions. Intriguingly, the ccA- and ccB-classifi...Continue Reading

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Citations

Apr 7, 2017·American Journal of Physiology. Renal Physiology·Roman Shingarev, Edgar A Jaimes
Oct 30, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Kimryn RathmellW Marston Linehan
Jan 29, 2018·Current Urology Reports·José I López, Javier C Angulo
Feb 22, 2017·Oncotarget·Bradley I Reinfeld, W Kimryn Rathmell
Jun 23, 2016·Molecular Cancer Research : MCR·Scott M HaakeW Kimryn Rathmell

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