Alternately pulsed nanoelectrospray ionization/atmospheric pressure chemical ionization for ion/ion reactions in an electrodynamic ion trap.

Analytical Chemistry
Xiaorong LiangScott A McLuckey

Abstract

The alternate operation of nanoelectrospray ionization and atmospheric pressure chemical ionization, using a common atmosphere/vacuum interface and ion path, has been implemented to facilitate ion/ion reaction experiments in a linear ion trap-based tandem mass spectrometer. The ion sources are operated in opposite polarity modes whereby one of the ion sources is used to form analyte ions while the other is used to form reagent ions of opposite polarity. This combination of ion sources is well-suited to implementation of experiments involving multiply charged ions in reaction with singly charged ions of opposite polarity. Three analytically useful ion/ion reaction types are illustrated: the partial deprotonation of a multiply protonated protein, the partial protonation of a multiply deprotonated oligonucleotide, and electron transfer to a multiply protonated peptide. The approach described herein is attractive in that it enables both single proton-transfer and single electron-transfer ion/ion reaction experiments to be implemented without requiring major modifications to the tandem mass spectrometer hardware. Furthermore, a wide range of reactant ions can be formed with these ionization methods and the pulsed nature of operation...Continue Reading

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Citations

Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Marija Mentinova, Scott A McLuckey
Nov 15, 2011·Journal of the American Society for Mass Spectrometry·Marija MentinovaScott A McLuckey
Dec 5, 2012·Journal of the American Society for Mass Spectrometry·Boone M PrenticeScott A McLuckey
Mar 7, 2013·Journal of the American Society for Mass Spectrometry·Ian K WebbScott A McLuckey
Apr 10, 2013·Journal of the American Society for Mass Spectrometry·Marija MentinovaScott A McLuckey
May 25, 2013·Journal of the American Society for Mass Spectrometry·Boone M PrenticeScott A McLuckey
Nov 15, 2006·Journal of the American Society for Mass Spectrometry·Xiaorong LiangScott A McLuckey
Aug 28, 2007·Journal of the American Society for Mass Spectrometry·Xiaorong LiangScott A McLuckey
Dec 18, 2007·Journal of the American Society for Mass Spectrometry·Yu Xia, Scott A McLuckey
Oct 8, 2008·Journal of the American Society for Mass Spectrometry·Matthew W SoykEthan R Badman
May 5, 2009·Journal of the American Society for Mass Spectrometry·David M Crizer, Scott A McLuckey
Jun 6, 2009·Journal of the American Society for Mass Spectrometry·Qin ZhaoEthan R Badman
Jun 23, 2009·Journal of the American Society for Mass Spectrometry·J Larry CampbellJ C Yves Le Blanc
Jan 19, 2010·Journal of the American Society for Mass Spectrometry·Teng-Yi HuangScott A McLuckey
Apr 15, 2009·Analytical Chemistry·Joshua J Coon
Jul 26, 2007·Chemical Reviews·Tao LiuRichard D Smith
May 9, 2013·Chemical Reviews·František Tureček, Ryan R Julian
Dec 7, 2010·Journal of the American Chemical Society·Marija Mentinova, Scott A McLuckey
Apr 1, 2009·Journal of the American Chemical Society·Chang Ho SohnJ L Beauchamp
Mar 28, 2008·Journal of Proteome Research·Nicolas J HauserFranco Basile
Jul 24, 2008·Journal of Proteome Research·Hongling HanScott A McLuckey
Jul 11, 2008·Journal of Proteome Research·Graeme C McAlisterJoshua J Coon
Jul 2, 2010·The Review of Scientific Instruments·Matthew J MyerAllison S Danell
Mar 29, 2014·Journal of the American Society for Mass Spectrometry·Alice L Pilo, Scott A McLuckey
Aug 8, 2008·Mass Spectrometry Reviews·Richard H PerryRobert J Noll
Jan 17, 2012·Proteomics·Min-Sik Kim, Akhilesh Pandey
Nov 26, 2013·International Journal of Mass Spectrometry·Boone M PrenticeScott A McLuckey
Feb 11, 2015·Journal of the American Society for Mass Spectrometry·Andrew N KrutchinskyBrian T Chait
Jan 7, 2015·Journal of the American Society for Mass Spectrometry·Carl A LuongoScott A McLuckey
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Alice L PiloScott A McLuckey
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·William M McGee, Scott A McLuckey
Aug 4, 2007·Molecular & Cellular Proteomics : MCP·David M GoodJoshua J Coon
Oct 4, 2018·Rapid Communications in Mass Spectrometry : RCM·Nan WangScott A McLuckey
Jan 31, 2007·Journal of Mass Spectrometry : JMS

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