Alternating current electrospinning for preparation of fibrous drug delivery systems

International Journal of Pharmaceutics
Attila BaloghZsombor Kristóf Nagy

Abstract

Alternating current electrospinning (ACES) was compared to direct current electrospinning (DCES) for the preparation of drug-loaded nanofibrous mats. It is generally considered that DCES is the solely technique to produce nanofibers using the electrostatic force from polymer solutions, however, less studied and also capable ACES provides further advantages such as increased specific productivities. A poorly water-soluble drug (carvedilol) was incorporated into the fibers based on three different polymeric matrices (an acid-soluble terpolymer (Eudragit(®) E), a base-soluble copolymer (Eudragit(®) L 100-55) and a nonionic homopolymer (polyvinylpyrrolidone K90)) to improve the dissolution of the weak base drug under different pH conditions. Morphology and fiber diameter evaluation showed similar electrospun fibers regardless the type of the high voltage and the major differences in feeding rates. The amorphous ACES and DCES fibers provided fast and total drug dissolutions in all cases. The presented results show that ACES can be a more feasible novel alternative to formulate fibers for drug delivery purposes.

References

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Mar 23, 2011·Analytical Chemistry·Nishant ChetwaniHsueh-Chia Chang
Sep 16, 2011·Journal of Pharmaceutical Sciences·Zsombor K NagyGyörgy Marosi
Feb 20, 2014·Journal of Pharmaceutical Sciences·Attila BaloghZsombor Kristóf Nagy
Jul 30, 2014·International Journal of Pharmaceutics·Petr VrbataMilan Lázníček
Nov 7, 2014·Physical Chemistry Chemical Physics : PCCP·P PokornyD Lukas
Dec 3, 2014·International Journal of Pharmaceutics·V GordonS Magdassi
Jan 18, 2015·International Journal of Pharmaceutics·Zsombor K NagyMarcus E Brewster
Mar 4, 2015·Current Pharmaceutical Design·Bo ShiXuesi Chen
Mar 13, 2015·Journal of Pharmaceutical Sciences·Attila BaloghGyörgy Marosi
Apr 2, 2015·International Journal of Pharmaceutics·B DémuthM E Brewster
Jun 6, 2015·International Journal of Pharmaceutics·Xia WangGareth R Williams
Aug 6, 2015·ACS Applied Materials & Interfaces·Deng-Guang YuGareth R Williams

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Citations

May 13, 2017·International Journal of Pharmaceutics·Olivera KaljevićSvetlana Ibrić
Apr 16, 2020·Antibiotics·Catarina S MirandaHelena P Felgueiras
Dec 22, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Panna VassZsombor K Nagy
Sep 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alex M JordanLaShanda T J Korley

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