Alternating Magnetic Field Controlled Targeted Drug Delivery Based on Graphene Oxide-Grafted Nanosupramolecules.

Chemistry : a European Journal
Bing ZhangYu Liu

Abstract

Graphene oxide (GO)-grafted nanosupramolecules have recently emerged as neoteric nano drug carriers in the therapy of refractory diseases. Herein, a multicomponent nanosupramolecular drug carrier based on a targeted peptide and magnetic GO is reported, the drug-release behavior of which can be regulated by an alternating magnetic field (AMF). This multicomponent nanosupramolecular carrier is composed of β-cyclodextrin (β-CD)/nickel nanoparticle-modified graphene oxide (GONiCD) and mitochondrial ion-targeting peptide (MitP)-grafted hyaluronic acid (HAMitP). Owing to the host-guest interaction between β-cyclodextrin and the cyclohexyl groups on MitP, GONiCD and HAMitP could form supramolecular assemblies during the doxorubicin (Dox) loading process, which not only remarkably enhances the drug-loading capacity, but also improves the drug-release efficiency under AMF stimulus. During co-incubation with tumor cells, the Dox-loaded assemblies could strongly target the tumor mitochondria and damage both the mitochondria and the nuclei, owing to Dox release from the assemblies induced by AMF. This study sheds light on the exploration of peptide caps for controlled drug loading/release of supramolecular nanocarriers for efficient drug d...Continue Reading

References

Aug 5, 2010·Journal of the American Chemical Society·Courtney R ThomasJeffrey I Zink
Mar 31, 2011·Advanced Drug Delivery Reviews·Challa S S R Kumar, Faruq Mohammad
Oct 11, 2011·Journal of the American Chemical Society·Neetu SinghSangeeta N Bhatia
Jan 5, 2012·Chemical Society Reviews·Zongxi LiJeffrey I Zink
Mar 14, 2013·Accounts of Chemical Research·Chul ChungDal-Hee Min
Sep 16, 2014·Chemical Communications : Chem Comm·Ying-Ming ZhangYu Liu
Feb 14, 2015·Chemical Communications : Chem Comm·Susana M N SimõesCarmen Alvarez-Lorenzo
Apr 29, 2015·Chemical Reviews·Pamela T Wong, Seok Ki Choi
Oct 6, 2015·Advanced Materials·Wei CuiGero Decher
Jan 6, 2016·ACS Applied Materials & Interfaces·Rosa GarrigaEdgar Muñoz
Feb 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Siaw Fui KiewLip Yong Chung
May 10, 2016·ACS Applied Materials & Interfaces·Fatemeh NasrollahiAli Jahanian-Najafabadi
Feb 28, 2017·Biochimica Et Biophysica Acta. General Subjects·Damien MertzSylvie Bégin-Colin
Aug 23, 2017·Chemical Society Reviews·Matthew J Webber, Robert Langer
Jul 3, 2018·ACS Applied Materials & Interfaces·Mijin KooEun Seong Lee
Oct 20, 2018·Advanced Drug Delivery Reviews·María MorosJesús Martínez de la Fuente
Jan 5, 2019·Journal of the American Chemical Society·Peng YangNiveen M Khashab
Feb 12, 2019·Drug Metabolism Reviews·Seyyed Mojtaba MousaviOmid Arjmand
Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Jun 28, 2019·Theranostics·Adam S Braegelman, Matthew J Webber
Jun 28, 2019·Theranostics·Nan SongYing-Wei Yang
Nov 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang WangYuxin Pei

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.