Alternating Magnetic Field Controlled, Multifunctional Nano-Reservoirs: Intracellular Uptake and Improved Biocompatibility.

Nanoscale Research Letters
Santaneel GhoshDianna L Hynds

Abstract

Biocompatible magnetic nanoparticles hold great therapeutic potential, but conventional particles can be toxic. Here, we report the synthesis and alternating magnetic field dependent actuation of a remotely controllable, multifunctional nano-scale system and its marked biocompatibility with mammalian cells. Monodisperse, magnetic nanospheres based on thermo-sensitive polymer network poly(ethylene glycol) ethyl ether methacrylate-co-poly(ethylene glycol) methyl ether methacrylate were synthesized using free radical polymerization. Synthesized nanospheres have oscillating magnetic field induced thermo-reversible behavior; exhibiting desirable characteristics comparable to the widely used poly-N-isopropylacrylamide-based systems in shrinkage plus a broader volumetric transition range. Remote heating and model drug release were characterized for different field strengths. Nanospheres containing nanoparticles up to an iron concentration of 6 mM were readily taken up by neuron-like PC12 pheochromocytoma cells and had reduced toxicity compared to other surface modified magnetic nanocarriers. Furthermore, nanosphere exposure did not inhibit the extension of cellular processes (neurite outgrowth) even at high iron concentrations (6 mM),...Continue Reading

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Citations

Apr 10, 2013·Journal of Biomaterials Science. Polymer Edition·Maria E NashCarlos Elvira
Jan 14, 2012·Advanced Drug Delivery Reviews·Somesree GhoshMitraSantaneel Ghosh
Mar 31, 2011·Advanced Drug Delivery Reviews·Challa S S R Kumar, Faruq Mohammad
Dec 31, 2010·Journal of Colloid and Interface Science·Fatih BuyukserinGurer Guven Budak
Nov 7, 2015·Journal of Biomaterials Science. Polymer Edition·Karolyn BarkerTania Betancourt
Apr 10, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert YokelRobert MacPhail
Nov 28, 2012·Advanced Healthcare Materials·Ashley M HawkinsJ Zach Hilt
Dec 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federico D'AgataCaterina Guiot
Nov 1, 2020·International Journal of Biological Macromolecules·Mayara de Freitas E CastroRubén J Sanchez Rodriguez
Nov 26, 2014·Chemical Reviews·Eun-Kyung LimKwangyeol Lee

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Methods Mentioned

BETA
electron microscopy
dynamic light scattering
confocal microscopy

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