Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Petra FischerHuiling Tan

Abstract

Gait disturbances in Parkinson's disease are commonly refractory to current treatment options and majorly impair patient's quality of life. Auditory cues facilitate gait and prevent motor blocks. We investigated how neural dynamics in the human subthalamic nucleus of Parkinsons's disease patients (14 male, 2 female) vary during stepping and whether rhythmic auditory cues enhance the observed modulation. Oscillations in the beta band were suppressed after ipsilateral heel strikes, when the contralateral foot had to be raised, and reappeared after contralateral heel strikes, when the contralateral foot rested on the floor. The timing of this 20-30 Hz beta modulation was clearly distinct between the left and right subthalamic nucleus, and was alternating within each stepping cycle. This modulation was similar, whether stepping movements were made while sitting, standing, or during gait, confirming the utility of the stepping in place paradigm. During stepping in place, beta modulation increased with auditory cues that assisted patients in timing their steps more regularly. Our results suggest a link between the degree of power modulation within high beta frequency bands and stepping performance. These findings raise the possibilit...Continue Reading

Citations

Sep 11, 2020·The European Journal of Neuroscience·Nadine Svenja Josée JacobsenStefan Debener
Feb 23, 2020·Scientific Reports·Luisa RoederGraham K Kerr
Jan 5, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Wolf-Julian NeumannR Mark Richardson
Sep 11, 2019·Brain : a Journal of Neurology·Nicoló G PozziIoannis U Isaias
Sep 4, 2019·Nature Biotechnology·Hayriye CagnanPeter Brown
Oct 28, 2019·Brain : a Journal of Neurology·Daniel WeissSimon J G Lewis
Nov 17, 2020·Frontiers in Human Neuroscience·Doris D Wang, Julia T Choi
Dec 18, 2019·Neuroscience and Biobehavioral Reviews·Loïc DammBenoît Bardy
Nov 27, 2020·Frontiers in Neurology·J Sebastian MarquezOu Bai
Aug 2, 2020·Brain Stimulation·Dan Piña-FuentesMartijn Beudel
Feb 22, 2021·Brain Stimulation·Kenneth H LouieScott E Cooper
Aug 11, 2020·Journal of Parkinson's Disease·Joyce B WeersinkBauke M de Jong
May 14, 2021·Frontiers in Human Neuroscience·Joshua K WongLeonardo Almeida
Apr 28, 2021·The European Journal of Neuroscience·Elena M BelovaAlexey Sedov
Jul 16, 2021·Neurodegenerative Disease Management·Daniel SiricaKarlo J Lizárraga
Jul 31, 2021·Nature Reviews. Neuroscience·Ricci Hannah, Adam R Aron

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