Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet

Molecular Nutrition & Food Research
Nadeem O KaakoushMargaret J Morris

Abstract

Overconsumption of energy-rich food is a major contributor to the obesity epidemic. The eating habits of many people are characterized by the cycling between overconsumption of energy-rich foods and dieting, the effects of which on the microbiota are currently unknown. We compared the fecal microbiota of rats either continuously fed chow or palatable cafeteria diet to a "cycled" group switched between the two diets (chow for 4, cafeteria for 3 days/wk, n = 12/group) over 16 wk. Enriched bacterial metabolic pathways were predicted, and a range of metabolic parameters was correlated to microbial taxa and pathways. Cycled rats showed large excursions in food intake on each diet switch. When switched from chow to cafeteria, they overconsumed, and when switched back to chow they underconsumed relative to those maintained on the two diets. Metabolic parameters of cycled rats were intermediate between those of the other diet groups (p < 0.05). The microbiota of cycled rats was nearly indistinguishable from rats under constant cafeteria diet, and both groups were significantly different to the chow group. Correlation analyses identified microbial metabolic pathways associated with an obese phenotype. These data suggest that continuous ...Continue Reading

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Citations

Jul 29, 2016·FEMS Microbiology Ecology·Nadeem O Kaakoush, Margaret J Morris
Dec 19, 2018·Frontiers in Endocrinology·Shyam Prakaash Bhagavata SrinivasanMargaret J Morris
Nov 9, 2016·Disease Models & Mechanisms·Perry BarrettPeter J Morgan
Feb 3, 2021·Gut Microbes·Xuemei LiuWei Chen
Jan 1, 2019·Current Pharmacology Reports·Ran YinAh-Ng Kong

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