Alternating two finger tapping with contralateral activation is an objective measure of clinical severity in Parkinson's disease and correlates with PET

Parkinsonism & Related Disorders
P K. PalJ K.C. Tsui

Abstract

We explored an objective method of measuring clinical severity of Parkinson's disease. Eighty-six patients with PD and 136 healthy subjects were studied. We serially carried out four types of finger tapping (FT) using a computerized drum machine: (i) repetitive one-finger tapping with an index-finger (F1K1); (ii) one-finger tapping on two keys separated by 20cm (F1K2); (iii) alternate tapping with index and middle fingers on two adjacent keys (F2K2); and (iv) F2K2 with contralateral activation (aF2K2). Analyses on FT included: (i) age and gender effects in healthy volunteers and Parkinson's disease; (ii) comparison between Parkinson patients and controls of similar age distribution; (iii) correlation with the Purdue Pegboard and Modified Columbia Scale in Disease; and (iv) in a subset of patients in whom PET scans were performed (n=30), correlation with 18F-DOPA uptake constant (Ki). In healthy subjects, there was a negative age effect on FT scores and a gender effect, with males scoring higher than females. All FT scores were significantly lower in the Parkinson patients, correlated with Purdue Peg Board, and inversely with the duration of illness, and with the Modified Columbia Scale. The 18F-DOPA Ki correlated significantly ...Continue Reading

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Citations

Nov 11, 2009·Journal of Neural Transmission·Thomas Müller, Ali Harati
Nov 4, 2008·Clinical Neuropharmacology·Steven A GunzlerJohn G Nutt
Apr 1, 2007·Neuropsychiatric Disease and Treatment·Thomas Müller
Dec 17, 2009·Parkinsonism & Related Disorders·Susan CriswellBrad A Racette
Jun 3, 2008·Seminars in Nuclear Medicine·Jeffrey H Meyer
Dec 8, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Peter H KrausHorst Przuntek
Jun 23, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Thomas MüllerDirk Woitalla
Jun 20, 2015·Parkinson's Disease·Wing Lok AuLouis Chew Seng Tan
Jan 21, 2016·Journal of Clinical Movement Disorders·Megan H TragerHelen Bronte-Stewart
Oct 2, 2012·Experimental Neurology·David T BrockerWarren M Grill
May 23, 2018·The European Journal of Neuroscience·Mauro Ursino, Chiara Baston
Dec 3, 2009·Medicine and Science in Sports and Exercise·Tomoko Aoki, Yoshiyuki Fukuoka
Jan 6, 2017·Science Translational Medicine·David T BrockerWarren M Grill
Jul 5, 2018·Journal of Neural Transmission·S H LeeM S Lee
Nov 20, 2018·Neuro-degenerative Diseases·Spyros PapapetropoulosDavid L Gray

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