Alternation of extracellular matrix remodeling and apoptosis by activation of the aryl hydrocarbon receptor pathway in human periodontal ligament cells

Journal of Cellular Biochemistry
A TomokiyoA Akamine

Abstract

It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Recent experiments have shown the induction of impaired tooth and hard-tissue formation by AhR pathway activation, however, the effect on periodontal ligament (PDL) tissue remains unclear. Here, we investigated the effects of benzo(a)pyrene (BaP), a member of PAH, on the extracellular matrix (ECM) remodeling-related molecules, collagen type I (COL-I), matrix metalloproteinase-1 (MMP-1), alpha-smooth muscle actin (α-SMA) expression, and apoptosis in two different human periodontal ligament cells (HPDLCs). The transduction of AhR from the cytoplasm to the nucleus and the increase of AhR-responsive genes; that is, cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), and aryl-hydrocarbon receptor repressor (AhRR), expression was induced by BaP exposure in both HPDLCs. BaP treatment significantly enhanced MMP-1 mRNA expression and MMP-1 protein production, while markedly suppressing COL-I and a-SMA mRNA expression in both HPDLCs. Furthermore, these BaP-treated HPDLCs fell into apoptotic cell death as evidenced by induction in annexin V and caspase-3/7 stai...Continue Reading

References

May 1, 1992·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·K ShimizuM Aono
Jan 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J BeckerH R Gelderblom
Mar 1, 1988·The Journal of Cell Biology·P BoukampN E Fusenig
Apr 17, 1995·Biochemical and Biophysical Research Communications·R WannerT Rosenbach
Apr 1, 1994·Journal of Cellular Physiology·P D Arora, C A McCulloch
Dec 1, 1995·Annals of the Rheumatic Diseases·S MaedaM Sakurai
Sep 1, 1996·Toxicology and Applied Pharmacology·P M Fernandez-SalgueroF J Gonzalez
Mar 1, 1997·Critical Reviews in Toxicology·J C Rowlands, J A Gustafsson
Aug 26, 1998·Toxicology and Applied Pharmacology·V M Salas, S W Burchiel
Jan 14, 1999·Genes & Development·J MimuraY Fujii-Kuriyama
Sep 14, 2000·Neuroscience Letters·A LeakeJ Whateley
Nov 14, 2000·The American Journal of Pathology·J C Reed
Dec 2, 2000·Journal of Orthodontics·J J KerriganJ R Sandy
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·G I MurrayM D Burke
May 1, 2001·Journal of Periodontal Research·P LekicC A McCulloch
Aug 4, 2001·Toxicology and Applied Pharmacology·H KattainenM Viluksela
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Yoshiyuki IshiiHiroyasu Esumi
Mar 6, 2003·Microscopy Research and Technique·Masaki ShimonoTakashi Inoue
Aug 21, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jie WuDarryl B Hood
Feb 27, 2004·The Journal of Biological Chemistry·Togo IkutaKaname Kawajiri
Jan 22, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexis DesmoulièreGiulio Gabbiani
Aug 27, 2005·Oral Diseases·Ll LoroA C Johannessen
Jan 25, 2007·International Dental Journal·Satu Alaluusua, Pirjo-Liisa Lukinmaa

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Citations

May 23, 2014·Cell and Tissue Research·Yoko TeramatsuAkifumi Akamine
Jun 15, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Feng HuHong-Xiang Chen
Dec 14, 2018·Environmental Toxicology and Chemistry·Danielle K MatzSteven J Bursian
Jul 28, 2013·Journal of Applied Physiology·Jessica M BradleyJason D Gardner
Jan 12, 2021·Ecotoxicology and Environmental Safety·Yi-Hsin TsengJohn Yu

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