PMID: 9539073Apr 16, 1998Paper

Alternations of surface antigens on leukocytes after severe injury: correlation with infectious complications

Intensive Care Medicine
H C ShihC H Lee

Abstract

To investigate the alternations of surface antigens of leukocytes after severe injury and the correlation with clinical outcome. Emergency Department and Intensive Care Unit of a university hospital. Patients with severe trauma (injury severity score > 16) were enrolled. Those who were transferred or had critical injuries were excluded. Polymorphonuclear cells (PMN) and mononuclear cells (MN) were isolated from patients on the 1st, 3rd and 7th day following injury. The mean fluorescent expressions of CD11b and CD16 of PMN, and CD25 of MN were measured and compared with those obtained from paralleled controls. Sixteen injured patients were included. The CD11b expressions of PMN increased on the 1st day and were still high on the 7th day. The CD16 expressions decreased on the 1st day and CD25 decreased on the 3rd day; both were still low on the 7th day. Six patients developed infectious complications. CD11b expression remained high and CD16 expression remained low on three measurements of the infectious patients, whereas both expressions recovered on the last measurement of non-infectious patients. CD25 expression remained low in both groups. Three infectious patients with pneumonia died from multiple organ failure. Phenotypic al...Continue Reading

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Citations

Jul 19, 2005·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Bruce H Davis, Nancy C Bigelow
Aug 12, 2014·Injury·Jon HazeldineJanet M Lord
Dec 3, 2014·Burns : Journal of the International Society for Burn Injuries·Liangyun ShenQian Tan
Apr 4, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M HolubA Lobovská
May 25, 1999·The Journal of Trauma·H OguraH Sugimoto
Jun 12, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Jiajia JinYong Song
May 11, 2006·Archives of Pathology & Laboratory Medicine·Bruce H DavisNancy C Bigelow

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