Alternative approaches to antiviral treatments: focusing on glycosylation as a target for antiviral therapy

Biotechnology and Applied Biochemistry
Tony Merry, Sviatlana Astrautsova

Abstract

Development of effective and safe medication for the treatment of viral infections remains a major challenge for the pharmaceutical industry in the 21st Century. There are numerous problems with the existing antiviral treatments both in terms of their safety and, in some cases, their cost, and they cannot be used generally but only in special circumstances. However, the threat of viral diseases ranging from AIDS and hepatitis C to influenza is increasing each year and there is considerable interest in safer and more generally applicable alternative treatments. It has been recognized for some time that some viruses have glycosylation features that are essential to their infectivity, but a means of providing a therapeutic route that is based on this has not been easy to exploit. In recent years, a number of possible approaches have been investigated and some of these are now considered to be realistic forms of therapy. Generally, approaches based on inhibition of the host machinery to glycosylate viral proteins or the ability of compounds to mimic the surface glycosylation of the virus seem to offer the best potential approaches. In this mini-review article, we look at recent advances in both of these areas and their potential to...Continue Reading

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Citations

Nov 6, 2013·FEMS Microbiology Reviews·Wander Van BreedamHans J Nauwynck
Jun 8, 2018·Glycobiology·Victoria OrtegaHector C Aguilar
Jan 14, 2021·Foods·Aroa Lopez-SantamarinaAlberto Cepeda

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