Alternative blood products and clinical needs in transfusion medicine.

Stem Cells International
Carolyn WhitsettGiuliano Grazzini

Abstract

The primary focus of national blood programs is the provision of a safe and adequate blood supply. This goal is dependent on regular voluntary donations and a regulatory infrastructure that establishes and enforces standards for blood safety. Progress in ex vivo expansion of blood cells from cell sources including peripheral blood, cord blood, induced pluripotent stem cells, and human embryonic stem cell lines will likely make alternative transfusion products available for clinical use in the near future. Initially, alloimmunized patients and individuals with rare blood types are most likely to benefit from alternative products. However, in developed nations voluntary blood donations are projected to be inadequate in the future as blood usage by individuals 60 years and older increases. In developing nations economic and political challenges may impede progress in attaining self-sufficiency. Under these circumstances, ex vivo generated red cells may be needed to supplement the general blood supply.

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Citations

Sep 9, 2020·Open Biology·Ravikant PiyushShashikant Ray
Aug 31, 2019·Stem Cells International·Yoojin SeoHyung-Sik Kim

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Methods Mentioned

BETA
blood collections
coronary artery bypass
flow cytometry

Clinical Trials Mentioned

NCT01297543
NCT00458783
NCT00991341

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