Alternative delivery of a thermostable inactivated polio vaccine

Vaccine
Heleen KraanJean-Pierre Amorij

Abstract

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants, have the potential to deliver vaccines outside the cold-chain and administer them without the use of needles and syringes. In the current study, Bioneedles were filled with IPV, subsequently lyophilized, and antigenic recoveries were determined both directly after IPV-Bioneedle preparation as well as after elevated stability testing. Further, we assessed the immunogenicity of IPV-Bioneedles in rats and the residence time at the site of administration. Trivalent IPV was formulated in Bioneedles with recoveries of 101±10%, 113±18%, and 92±15%, respectively for serotypes 1, 2 and 3. IPV in Bioneedles is more resistant to elevated temperatures than liquid IPV: liquid IPV retained less than half of its antigenicity after 1 day at 45°C and IPV in Bioneedles showed remaining recoveries of 80±10%, 85±4% and 63±4% for the three serotypes. In vivo imaging revealed that IPV administered via Bioneedles as well as subcutaneously injected li...Continue Reading

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Apr 25, 2014·Pharmaceutical Research·Heleen KraanJean-Pierre Amorij
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Jun 26, 2014·Expert Opinion on Drug Delivery·Peggy RieseCarlos A Guzmán

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Citations

Feb 19, 2016·Expert Review of Vaccines·Sergio Rosales-MendozaRalf Reski
Feb 26, 2016·Expert Review of Vaccines·Heleen KraanJean-Pierre Amorij
May 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stephany Y TzengAna Jaklenec
May 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Stephany Y TzengAna Jaklenec
Jan 6, 2019·AAPS PharmSciTech·N DumpaS Narasimha Murthy
Jun 21, 2017·Vaccine·Bruce Y Lee, Leila A Haidari

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