Abstract
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants, have the potential to deliver vaccines outside the cold-chain and administer them without the use of needles and syringes. In the current study, Bioneedles were filled with IPV, subsequently lyophilized, and antigenic recoveries were determined both directly after IPV-Bioneedle preparation as well as after elevated stability testing. Further, we assessed the immunogenicity of IPV-Bioneedles in rats and the residence time at the site of administration. Trivalent IPV was formulated in Bioneedles with recoveries of 101±10%, 113±18%, and 92±15%, respectively for serotypes 1, 2 and 3. IPV in Bioneedles is more resistant to elevated temperatures than liquid IPV: liquid IPV retained less than half of its antigenicity after 1 day at 45°C and IPV in Bioneedles showed remaining recoveries of 80±10%, 85±4% and 63±4% for the three serotypes. In vivo imaging revealed that IPV administered via Bioneedles as well as subcutaneously injected li...Continue Reading
References
Nov 1, 1980·The Journal of General Virology·P D MinorC N Dandawate
Apr 27, 1999·Vaccine·G KerstenC Beuvery
Jan 1, 1963·Archiv für die gesamte Virusforschung·J NAGELH COHEN
Sep 21, 2004·The Journal of Infectious Diseases·Eugenia M DragunskyKonstantin M Chumakov
Apr 15, 2008·Vaccine·Hoang J H B HirschbergGideon F A Kersten
Feb 28, 2009·Nature Reviews. Immunology·Philippa MarrackMichael W Munks
Sep 5, 2009·Vaccine·Chunting YangHonglin Xu
Jan 29, 2010·Clinical and Vaccine Immunology : CVI·Jesús ArenasPeter van der Ley
May 28, 2010·Biotechnology and Bioengineering·Yvonne E ThomassenWilfried A M Bakker
Jul 14, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hoang J H B HirschbergGideon F A Kersten
Dec 8, 2010·Vaccine·Susan L BaldwinMartin Friede
Mar 15, 2011·Vaccine·Janny WestdijkGideon Kersten
Mar 18, 2011·Journal of Medical Virology·Y GhendonG Krivtsov
Dec 14, 2011·Biologicals : Journal of the International Association of Biological Standardization·R ten HaveG Zomer
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Pierre AmorijWim Jiskoot
Jan 15, 2013·Vaccine·Janny WestdijkGideon Kersten
Jun 19, 2013·Vaccine·Darius SoonawalaNynke Y Rots
Dec 18, 2013·Vaccine·Benjamin P SteilMario Barro
Jan 29, 2014·Pharmaceutical Research·Koen van der MaadenJoke Bouwstra
Feb 12, 2014·Expert Review of Vaccines·Christian Herzog
Apr 25, 2014·Pharmaceutical Research·Heleen KraanJean-Pierre Amorij
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heleen KraanJean-Pierre Amorij
Jun 26, 2014·Expert Opinion on Drug Delivery·Peggy RieseCarlos A Guzmán
Citations
Feb 19, 2016·Expert Review of Vaccines·Sergio Rosales-MendozaRalf Reski
Feb 26, 2016·Expert Review of Vaccines·Heleen KraanJean-Pierre Amorij
May 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stephany Y TzengAna Jaklenec
Jun 19, 2016·Pharmaceutical Research·Pim SchipperJoke Bouwstra
May 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Stephany Y TzengAna Jaklenec
Jan 6, 2019·AAPS PharmSciTech·N DumpaS Narasimha Murthy
Mar 12, 2021·Journal of Global Health·Ibrahim K Dadari, Janice C Zgibor
Jun 21, 2017·Vaccine·Bruce Y Lee, Leila A Haidari