Alternative diastolic function models of ventricular longitudinal filling velocity are mathematically identical.

American Journal of Physiology. Heart and Circulatory Physiology
Druv BhagavanSandor J Kovacs

Abstract

The spatiotemporal features of normal in vivo cardiac motion are well established. Longitudinal velocity has become a focus of diastolic function (DF) characterization, particularly the tissue Doppler e'-wave, manifesting in early diastole when the left ventricle (LV) is a mechanical suction pump (dP/dV < 0). To characterize DF and elucidate mechanistic features, several models have been proposed and have been previously compared algebraically, numerically, and in their ability to fit physiological velocity data. We analyze two previously noncompared models of early rapid-filling lengthening velocity (Doppler e'-wave): parametrized diastolic filling (PDF) and force balance model (FBM). Our initial numerical experiments sampled FBM-generated e'(t) contours as input to determine PDF model predicted fit. The resulting exact numerical agreement [standard error of regression (SER) = 9.06 × 10-16] was not anticipated. Therefore, we analyzed all published FBM-generated e'(t) contours and observed identical agreement. We re-expressed FBM's algebraic expressions for e'(t) and observed for the first time that model-based predictions for lengthening velocity by the FBM and the PDF model are mathematically identical: e'(t) = γe-αtsinh(βt),...Continue Reading

References

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Citations

Nov 14, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Junedh M AmruteSándor J Kovács

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Software Mentioned

MATLAB
Echo E - waves
RTab1

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