PMID: 8448552Jan 1, 1993Paper

Alternative donor transplants for leukemia. Scientific Advisory Committee of the International Bone Marrow Transplant Registry

Bone Marrow Transplantation
R P Gale, M M Horowitz

Abstract

We analyzed transplant outcome in more than 2,500 recipients of alternative donor and HLA-identical sibling transplants. These data indicate: (1) results of alternative donor transplants are inferior to HLA-identical sibling transplants; (2) zero HLA-antigen disparate unrelated and one HLA-antigen disparate related donors have comparable results; (3) amongst unrelated donors, zero and one HLA-antigen disparity has comparable results; and (4), amongst related transplants, two HLA-antigen disparate transplants fare worse than one HLA-antigen disparate transplants. These data should be useful in deciding when to use an alternative donor and selecting the best donor.

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