Alternative intraperitoneal chemotherapy regimens for optimally debulked ovarian cancer

Gynecologic Oncology
Heidi J GrayBarbara A Goff

Abstract

GOG 172 showed a survival benefit with intraperitoneal (IP) cisplatin for advanced ovarian cancer, but patients tolerated the regimen poorly. We hypothesized that women treated with alternative IP chemotherapy strategies may have less toxicity and improved compliance. We reviewed the records of women with ovarian cancer and optimal surgical debulking who underwent IP chemotherapy at our institution. Primary outcomes analyzed were completion rates and toxicities of IP chemotherapy. Secondary outcomes were progression-free and overall survival. Statistical analysis was performed using STATA 10.0. Thirty-nine patients with primary ovarian or peritoneal cancer who underwent IP chemotherapy were identified over a 2 year period. Patients were treated with IV paclitaxel followed by IP cisplatin (64%) or IP carboplatin (36%). Median two cycles of intravenous (IV) taxane and carboplatin were given prior to initiating IP therapy in 77% of patients. Median number of IP chemotherapy cycles was 5 and median total number of cycles was 8. Seventy-four percent (74%) of patients received four or greater cycles of IP chemotherapy. There was a higher rate of completion of intended number of IP cycles in the carboplatin group (92%) versus 60% in t...Continue Reading

References

Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert F OzolsUNKNOWN Gynecologic Oncology Group
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K FujiwaraM Markman
Feb 21, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S NagaoK Shimoya
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Sep 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura J HavrileskyUNKNOWN Gynecologic Oncology Group

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Citations

Jan 21, 2016·Nature Reviews. Clinical Oncology·Steven Narod
Mar 29, 2012·Expert Opinion on Drug Delivery·Payam ZahediChristine Allen
Oct 6, 2016·Journal of Microencapsulation·Anita Chudecka-GłazMiroslawa El Fray
May 10, 2016·Obstetrics and Gynecology·Jason D WrightDawn L Hershman
Mar 18, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tien LeMichael Fung-Kee-Fung
Jul 9, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ana OakninAndrés Poveda
Nov 22, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gema BruixolaAna Santaballa
Jan 13, 2016·The Cochrane Database of Systematic Reviews·Kenneth JaabackTheresa A Lawrie

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