Alternative methods for developmental toxicity testing

Basic & Clinical Pharmacology & Toxicology
A H Piersma

Abstract

Alternatives to animal testing in developmental toxicology have been the subject of three decades of research. The aims of these investigations have been to reduce animal experimentation, to refine effect assessment and mechanistic studies, and to accelerate and simplify safety testing in an area of toxicology that uses relatively many animals. Many alternatives have been developed over the years with different compexities, using biologic material ranging from continuous cell lines to complete embryos. The validation of alternatives and their application in testing strategies is still in its infancy, although significant steps towards these aims are currently being made. The introduction of the genomics technology is a promising emerging area in developmental toxicity testing in vitro. Future application of alternatives in testing strategies for developmental toxicity may significantly gain from the inclusion of gene expression studies, given the unique programme of gene expression changes in embryonic and foetal development.

References

May 1, 1988·Mutation Research·E M Faustman
Jul 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M GomiS Tarui
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R M Pratt, W D Willis
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·J E TroskoM Netzloff
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·R Jelinek
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·M K SmithJ G Wilson
Nov 1, 1984·Toxicology and Applied Pharmacology·O P Flint, T C Orton
May 1, 1995·Reproductive Toxicology·A H PiersmaC Verseil
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N I zur NiedenH J Ahr
Nov 8, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J RohwedelA M Wobus
Jul 27, 2002·Annual Review of Genomics and Human Genetics·Jordan T Shin, Mark C Fishman
May 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robert K Vinson, Barbara F Hales
Aug 14, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Estibaliz L FernándezLennart Dencker
Jan 3, 1959·Lancet·G F WILGRAM, W J TAYLOR
Feb 18, 2004·The Journal of Reproduction and Development·Satoshi ImanishiHajime Miyamoto
Feb 21, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Svetlana MikheevaPhilip E Mirkes
Aug 4, 2004·Environmental Health Perspectives·Jonathan G MoggsGeorge Orphanides
Sep 4, 2004·Environmental Health Perspectives·Kim KultimaMichael Stigson
Oct 12, 2004·Nature Genetics·Simon D BamforthShoumo Bhattacharya
Oct 27, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Cristian PellizzerSusanne Bremer
Nov 4, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Akinobu OkadaMichio Fujiwara
Feb 3, 2005·Reproductive Toxicology·Edward D KarolyE Sidney Hunter
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Heather M Handley-GoldstoneJohn J Stegeman
Mar 8, 2005·Reproductive Toxicology·Huaping ZhangZhongdong Qiao
Apr 29, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sheila M BellWilliam J Scott
Jun 22, 2005·Toxicology and Applied Pharmacology·Kimberly A NemethThomas B Knudsen
Sep 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A H PiersmaA M Hagenaars
Mar 26, 1996·Environmental Science & Technology·J Johnson

❮ Previous
Next ❯

Citations

May 25, 2011·Archives of Toxicology·Manfred LiebschAndreas Luch
Dec 29, 2013·Environmental Science & Technology·Beate I EscherFrederic D L Leusch
Jul 2, 2011·Nature Protocols·Andrea E M Seiler, Horst Spielmann
Dec 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Moo-Yeal LeeJonathan S Dordick
May 3, 2011·Archives of Toxicology·Sarah AdlerJosé-Manuel Zaldivar
Aug 1, 2014·Journal of Hazardous Materials·Michela GuarientiMarco Presta
Jan 27, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Roland BuesenAndrea Seiler
Nov 26, 2011·Expert Opinion on Drug Metabolism & Toxicology·Jochem LouisseIvonne M C M Rietjens
Jul 31, 2012·Toxicology and Applied Pharmacology·Joshua F RobinsonAldert H Piersma
May 21, 2008·Regulatory Toxicology and Pharmacology : RTP·Anthony R Scialli
Jul 31, 2007·Current Opinion in Chemical Biology·Gabriela Gebrin Cezar
Oct 21, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M FernándezL Calzà
Sep 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Susan L MakrisRochelle Tyl
Aug 18, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E TeixidóJ M Llobet
May 6, 2016·Environmental Pollution·Michela GuarientiMarco Presta
Jun 9, 2016·Toxicology Mechanisms and Methods·Luciana Rizzieri FigueiróAna Luiza Ziulkoski
Jan 21, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joshua F RobinsonAldert H Piersma
Jul 1, 2017·Experimental Biology and Medicine·T B KnudsenW Slikker
May 19, 2009·Reproductive Toxicology·Ingrid W T SelderslaghsHilda E Witters
Mar 1, 2016·Interdisciplinary Toxicology·Luciana Rizzieri FigueiróAna Luiza Ziulkoski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.