PMID: 11606797Oct 19, 2001Paper

Alternative models for carcinogenicity testing

Toxicological Sciences : an Official Journal of the Society of Toxicology
S M CohenJ S MacDonald

Abstract

The International Conference on Harmonisation Expert Working Group on Safety suggested that under certain circumstances, data from alternative assays could be used in safety evaluation in place of a second bioassay. Several alternatives were discussed. Six of these models were evaluated in a collaborative effort under the auspices of the Health and Environmental Sciences Institute (HESI) branch of the International Life Sciences Institute (ILSI). Standard protocols, pathology review, and statistical evaluations were developed. Twenty-one chemicals were evaluated, including genotoxic, nongenotoxic, carcinogenic, and noncarcinogenic chemicals. The models that were evaluated included the p53(+/-) heterozygous knockout mouse, the rasH2 transgenic mouse, the TgAC transgenic mouse (dermal and oral administration), the homozygous XPA knockout and the XPA/p53 knockout mouse models. Also evaluated were the neonatal mouse models and the Syrian Hamster Embryo (SHE) transformation assay. The results of this comprehensive study suggest that some of these models might be useful in hazard identification if used in conjunction with information from other sources in a weight of evidence, integrated analysis approach to risk assessment.

References

Mar 1, 1994·Toxicologic Pathology·G A BoormanS L Eustis
Feb 1, 1997·Regulatory Toxicology and Pharmacology : RTP·J P Van OosterhoutR Bass
Apr 1, 1997·Regulatory Toxicology and Pharmacology : RTP·J F ContreraJ J DeGeorge
Nov 14, 1997·Regulatory Toxicology and Pharmacology : RTP·T J FlammangP P Fu

❮ Previous
Next ❯

Citations

May 14, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·James S MacDonald, Richard T Robertson
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M Cohen, Lora L Arnold
Aug 25, 2012·Disease Models & Mechanisms·Aaron McCoyXiaoxia Cui
Aug 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas G OsimitzBrian G Lake
Jul 26, 2005·Inhalation Toxicology·David BernsteinUNKNOWN ILSI Risk Science Institute Working Group
May 20, 2006·Critical Reviews in Toxicology·John E DoeDouglas C Wolf
Nov 17, 2012·Toxicology and Applied Pharmacology·Joost P M MelisHarry van Steeg
Jan 8, 2009·Regulatory Toxicology and Pharmacology : RTP·Monique Y Wells, E Spencer Williams
Mar 11, 2016·The Journal of Toxicological Sciences·Masayuki KankiHideki Wanibuchi
Aug 30, 2013·Critical Reviews in Toxicology·David A EastmondBabasaheb Sonawane
Apr 18, 2012·Regulatory Toxicology and Pharmacology : RTP·David J Snodin, Sean D McCrossen
Nov 30, 2013·Regulatory Toxicology and Pharmacology : RTP·Palma Ann MaroneA Wallace Hayes
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·M GuérardR Froetschl
Dec 7, 2011·Critical Reviews in Toxicology·Tatyana Y DoktorovaVera Rogiers
Sep 17, 2003·The Journal of Toxicological Sciences·Urs A Boelsterli
Dec 19, 2002·Environmental Health Perspectives·Steve Wing, David Richardson
Dec 4, 2002·Environmental Health Perspectives·Frank M Johnson, James Huff
Mar 20, 2019·Pharmaceutical Development and Technology·Shereen M AssafAdnan Ali Badwan
Mar 13, 2020·Critical Reviews in Toxicology·Nigel J GooderhamSean V Taylor
Nov 1, 2008·Expert Review of Clinical Pharmacology·Ping GuanJoseph Sina
Jan 1, 2015·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Ayako Takei
Jun 15, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mark R FieldenJeremy Gollub

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.