PMID: 6864230Jul 1, 1983Paper

Alternative pathways of glucose utilization in brain: changes in the pattern of glucose utilization and of the response of the pentose phosphate pathway to 5-hydroxytryptamine during aging

Journal of Neurochemistry
S ZubairuA L GREENBAUM

Abstract

The oxidation of differentially labelled glucose, pyruvate and glutamate in brain slices from rats aged 20 days to 26 months has been studied and the partition of the glucose used into the glycolytic-tricarboxylic acid cycle pathway, the pentose phosphate pathway and the glutamate-GABA shunt has been calculated. Over the time range 4 to 26 months, there is an approximately 20% decrease in the production of CO2 via the glycolytic-tricarboxylic acid cycle route, as there is in the rate of glucose phosphorylation. The glutamate-GABA pathway falls by about 50% over this same time span. The broad activity of the pentose phosphate pathway falls rapidly and cannot be detected in the brains of rats aged 18 months or more, whereas the fully stimulated pathway, i.e. in the presence of the artificial electron acceptor phenazine methosulphate, declines only marginally over this period, falling sharply only after 23 months. The pentose phosphate pathway is stimulated by the presence of 5-hydroxytryptamine and this stimulation appears to increase with age.

References

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Citations

Apr 22, 2009·Biogerontology·Najma Z BaquerDeepak Sharma
Sep 10, 1986·Biochimica Et Biophysica Acta·J Vitórica, J Satrústegui
Jan 1, 1990·Neurochemistry International·N Z BaquerA L Greenbaum
Jul 1, 1995·Neurochemical Research·J A KelleherG A Gregory
Jun 21, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eva M F BrekkeUrsula Sonnewald
May 1, 1984·Journal of Neurochemistry·J R ViñaR A Hawkins
Oct 1, 1986·Cell Biochemistry and Function·T Wood
Jan 1, 1985·The American Journal of Physiology·R A HawkinsL S Hibbard
Oct 7, 1996·Brain Research·E L Roberts, T J Sick

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