journal cover

Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

Genome Research

Feb 8, 2020

Swati VenkatMichael E Feigin

Download from

Publisher
PubMed

Abstract

Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3'-UTR length, resulting in changes in mRNA stability and localization. APA is frequently disrupted in cancer and promotes tumorigenesis through altered expression of oncogenes and tumor suppressors. Pan-c...read more

Mentioned in this Paper

Survival Analysis
The Cancer Genome Atlas
Regulation of Biological Process
Oncogenes
Widespread
Pancreatic Ductal Adenocarcinoma
Tumor Suppressor Genes
3' Untranslated Regions
1,N(6)-propanodeoxyadenosine
Carcinogenesis
15
1
Paper Details
References
  • References103
  • Citations
12345...
  • References103
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Feeds With Similar Papers

Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma holds a significant mortality risk, largely due to its late diagnosis and ineffective chemotherapeutic response. This gastrointestinal malignancy offers a poor prognosis and the only potential cure is through surgical resection. Here are the latest discoveries pertaining to this disease.

MicroRNAs & Open Reading Frames

MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

Polyadenylation

Polyadenylation is the addition of a stretch of adenine bases to messenger RNA and other RNAs. Given that this processes is essential for the production of mature mRNA for translation, polyadenylation can regulate gene expression. Here is the latest research.

Mammalian Cell Cycle & Cell Growth Control

Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.

Related Papers

Journal of the National Cancer Institute

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer

Journal of the National Cancer InstituteNovember 7, 2017
Yu XiangLeng Han
© 2020 Meta ULC. All rights reserved

Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

Genome Research

Feb 8, 2020

Swati VenkatMichael E Feigin

PMID: 32029502

DOI: 10.1101/gr.257550.119

Abstract

Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3'-UTR length, resulting in changes in mRNA stability and localization. APA is frequently disrupted in cancer and promotes tumorigenesis through altered expression of oncogenes and tumor suppressors. Pan-c...read more

Mentioned in this Paper

Survival Analysis
The Cancer Genome Atlas
Regulation of Biological Process
Oncogenes
Widespread
Pancreatic Ductal Adenocarcinoma
Tumor Suppressor Genes
3' Untranslated Regions
1,N(6)-propanodeoxyadenosine
Carcinogenesis
15
1

Feeds With Similar Papers

Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma holds a significant mortality risk, largely due to its late diagnosis and ineffective chemotherapeutic response. This gastrointestinal malignancy offers a poor prognosis and the only potential cure is through surgical resection. Here are the latest discoveries pertaining to this disease.

MicroRNAs & Open Reading Frames

MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.

Related Papers

Journal of the National Cancer Institute

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer

Journal of the National Cancer InstituteNovember 7, 2017
Yu XiangLeng Han
Paper Details
References
  • References103
  • Citations
12345...
  • References103
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Download from

Publisher
PubMed
/papers/alternative-polyadenylation-drives-oncogenic-gene/32029502