Alternative Polyadenylation of mRNAs: 3'-Untranslated Region Matters in Gene Expression

Molecules and Cells
Hsin-Sung Yeh, Jeongsik Yong

Abstract

Almost all of eukaryotic mRNAs are subjected to polyadenylation during mRNA processing. Recent discoveries showed that many of these mRNAs contain more than one polyadenylation sites in their 3' untranslated regions (UTR) and that alternative polyadenylation (APA) is prevalent among these genes. Many biological processes such as differentiation, proliferation, and tumorigenesis have been correlated to global APA events in the 3' UTR of mRNAs, suggesting that these APA events are tightly regulated and may play important physiological roles. In this review, recent discoveries in the physiological roles of APA events, as well as the known and proposed mechanisms are summarized. Perspective for future directions is also discussed.

References

Nov 14, 1997·Genes & Development·D F Colgan, J L Manley
Jan 16, 1999·Nucleic Acids Research·J H GraberT F Smith
Oct 16, 1999·Cell·S M Barabino, W Keller
Jul 19, 2000·Genome Research·E BeaudoingD Gautheret
Dec 17, 2005·Genome Biology·Haibo ZhangBin Tian
Nov 28, 2006·The Journal of Biological Chemistry·Hui ZhuHua Lou
Apr 28, 2007·The EMBO Journal·Sven DanckwardtAndreas E Kulozik
Nov 4, 2008·Nature·Donny D LicatalosiRobert B Darnell
Apr 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zhe JiBin Tian
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Qin YangSylvie Doublié
Jun 11, 2010·Annual Review of Biochemistry·Marc Robert FabianWitold Filipowicz
Nov 19, 2010·Cell Cycle·Xiaokan ZhangFrida E Kleiman
Sep 8, 2011·Genes & Development·Nick J Proudfoot
Sep 20, 2011·Molecular Cell·Dafne Campigli Di GiammartinoJames L Manley
Mar 6, 2012·Cell Stem Cell·Stéphane C BoutetThomas A Rando
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
Jul 4, 2012·Genome Biology·Ran ElkonReuven Agami
Jul 10, 2012·Nucleic Acids Research·Eleonora de KlerkPeter A C 't Hoen
Aug 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam R MorrisReuven Agami
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chengguo YaoYongsheng Shi
Feb 26, 2013·Nature·Felice-Alessio BavaRaúl Méndez
May 2, 2013·Trends in Biochemical Sciences·Bin Tian, James L Manley
Jun 19, 2013·Nature Reviews. Genetics·Ran ElkonReuven Agami
May 13, 2014·Nature·Chioniso P MasamhaEric J Wagner

❮ Previous
Next ❯

Citations

Nov 1, 2016·Nature Reviews. Genetics·Jonathan M Mudge, Jennifer Harrow
Jun 14, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cheng-Zhou MaoXu-Feng Qi
Mar 5, 2019·The Journal of Clinical Investigation·Tingting WengMichael R Blackburn
Aug 9, 2019·Journal of Translational Medicine·Shirong ZhangShenglin Ma
Sep 7, 2019·The Journal of Biological Chemistry·Junsuk KoMichael R Blackburn
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Hsin-Sung Yeh, Jeongsik Yong
Nov 11, 2019·BMC Genomics·Zsolt BalázsZsolt Boldogkői
Mar 21, 2017·Cellular and Molecular Life Sciences : CMLS·Petra Björk, Lars Wieslander
Dec 29, 2016·Protein Science : a Publication of the Protein Society·Thomas C Custer, Nils G Walter
Apr 22, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lidia TagliafierroOrnit Chiba-Falek
Apr 8, 2020·BioMed Research International·Lulu DengChangchun Li
Dec 10, 2020·Biomarker Research·Fanggang RenJeffrey J Pu
Dec 10, 2020·Viruses·Iván Gabriel PerosPablo Daniel Ghiringhelli
Jul 9, 2021·Journal of Agricultural and Food Chemistry·Jianwei CuiGuoli Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.