Alternative promoter usage of the membrane glycoprotein CD36

BMC Molecular Biology
Malin AndersenJacob Odeberg

Abstract

CD36 is a membrane glycoprotein involved in a variety of cellular processes such as lipid transport, immune regulation, hemostasis, adhesion, angiogenesis and atherosclerosis. It is expressed in many tissues and cell types, with a tissue specific expression pattern that is a result of a complex regulation for which the molecular mechanisms are not yet fully understood. There are several alternative mRNA isoforms described for the gene. We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation. We have identified one novel alternative first exon of the CD36 gene, and confirmed the expression of four previously known alternative first exons of the gene. The alternative transcripts are all expressed in more than one human tissue and their expression patterns vary highly in skeletal muscle, heart, liver, adipose tissue, placenta, spinal cord, cerebrum and monocytes. All alternative first exons are upregulated in THP-1 macrophages in response to oxidized low density lipoproteins. The alternative promoters lack TATA-boxes and CpG islands. The upstream region of exon 1b contains several features...Continue Reading

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Datasets Mentioned

BETA
BG944316
DA741325
AF266759

Methods Mentioned

BETA
PMA
PCR
footprinting
MDA
electrophoresis

Software Mentioned

MatInspector
FANTOM
UCSC genome browser
Consite
FANTOM3
CAGE viewer
CAGE basic viewer
StatView
Gibbs Motif Sampler

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