Alternative quality control for technetium-99m IDA complexes

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Mervyn W BillinghurstKennedy Mang'era

Abstract

A quality control procedure for 99mTc-IDA complexes based on the use of C18 Sep-pak cartridges is developed and the validation of the procedure presented. C18 Sep-pak cartridges are pretreated by washing with 95% ethanol followed by 10(-3) N hydrochloric acid. A small amount of the 99mTc-IDA complex is applied, washed with 10(-3) N hydrochloric acid and eluted with 95% ethanol. The radiochemical purity values obtained for 99mTc-mebrofenin and 99mTc-disofenin using this Sep-pak procedure are comparable to those obtained using the standard two strip (ITLC-SG/100% methanol, ITLC-SA/20% saline) procedure.

References

Jan 1, 1982·International Journal of Nuclear Medicine and Biology·A R FritzbergW P Whitney

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Citations

Feb 5, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Kennedy Mang'eraTaddese Biru
Feb 27, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sara NeytFilip De Vos

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