Alternative splicing and cancer metastasis: prognostic and therapeutic applications

Clinical & Experimental Metastasis
Diego M MarzeseDave S B Hoon

Abstract

Metastatic cells exhibit an extraordinary phenotypic plasticity, not only in adapting to unfamiliar microenvironments but also in surviving aggressive treatments and immune responses. A major source of phenotypic variability is alternative splicing (AS) of the pre-messenger RNA. This process is catalyzed by one of the most complex pieces of cellular molecular regulatory events, the spliceosome, which is composed of ribonucleoproteins and polypeptides termed spliceosome factors. With strong evidence indicating that AS affects nearly all genes encoded by the human genome, aberrant AS programs have a significant impact on cancer cell development and progression. In this review, we present insights about the genomic and epigenomic factors affecting AS, summarize the most recent findings linking aberrant AS to metastatic progression, and highlight potential prognostic and therapeutic applications.

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Citations

Jun 21, 2020·Molecular Cancer Research : MCR·Jianguo HuangDavid G Kirsch
May 1, 2021·Genes·Zhongjing Su, Dongyang Huang
Aug 7, 2021·Genes·Nikolay MehterovVictoria Sarafian
Nov 19, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiu PengQianjin Liao

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Methods Mentioned

BETA
antisense oligonucleotides
Antisense
SMA

Clinical Trials Mentioned

NCT02841540
NCT02423590
NCT02507583
NCT01159028
NCT02923986
NCT02781883
NCT03101839
NCT03300505
NCT02549651
NCT03394144

Software Mentioned

SpliceSeq

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