Alternative splicing and gene duplication in the evolution of the FoxP gene subfamily.

Molecular Biology and Evolution
M Emília SantosElio Sucena

Abstract

The FoxP gene subfamily of transcription factors is defined by its characteristic 110 amino acid long DNA-binding forkhead domain and plays essential roles in vertebrate biology. Its four members, FoxP1-P4, have been extensively characterized functionally. FoxP1, FoxP2, and FoxP4 are involved in lung, heart, gut, and central nervous system (CNS) development. FoxP3 is necessary and sufficient for the specification of regulatory T cells (Tregs) of the adaptive immune system. In Drosophila melanogaster, in silico predictions identify one unique FoxP subfamily gene member (CG16899) with no described function. We characterized this gene and established that it generates by alternative splicing two isoforms that differ in the forkhead DNA-binding domain. In D. melanogaster, both isoforms are expressed in the embryonic CNS, but in hemocytes, only isoform A is expressed, hinting to a putative modulation through alternative splicing of FoxP1 function in immunity and/or other hemocyte-dependent processes. Furthermore, we show that in vertebrates, this novel alternative splicing pattern is conserved for FoxP1. In mice, this new FoxP1 isoform is expressed in brain, liver, heart, testes, thymus, and macrophages (equivalent in function to he...Continue Reading

References

Jul 1, 1991·Journal of Molecular Evolution·T Ohta
Nov 30, 1998·Science·A AmoresJ H Postlethwait
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Dec 1, 2001·Human Molecular Genetics·F A Kondrashov, E V Koonin
Apr 5, 2002·Advances in Genetics·Sarah P Otto, Paul Yong
Apr 8, 2003·Developmental Biology·Kyriakos D EconomidesMario R Capecchi
Apr 11, 2003·The Journal of Comparative Neurology·Russell J FerlandChristopher A Walsh
Jun 14, 2003·Science·Cyrus ChothiaSarah A Teichmann
Jun 24, 2003·Biochimica Et Biophysica Acta·Andreas TeufelHeiner Westphal
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Oct 18, 2003·Gene·Françoise MazetSebastian M Shimeld
Jan 28, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hsiu-Hsiang Lee, Manfred Frasch
Feb 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rabindra TirouvanziamLeonard A Herzenberg
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastian HaeslerConstance Scharff
Apr 21, 2004·The Journal of Biological Chemistry·Teresa R PachecoMaria Carmo-Fonseca
Aug 3, 2004·The Journal of Clinical Investigation·Can ShiDaniel I Simon
Oct 7, 2004·International Immunology·Haruhiko YagiShimon Sakaguchi
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Nov 23, 2005·Bioinformatics·Konstantin ArnoldTorsten Schwede
Dec 21, 2005·Genome Research·Zhixi SuXun Gu
Jan 13, 2006·Structure·James C StroudLin Chen
Apr 13, 2006·Development Genes and Evolution·Christian SchönWalter Knöchel
Jun 24, 2006·The Biochemical Journal·Patrick J E C WijchersMarten P Smidt
Jul 5, 2006·Nature Immunology·Hui HuAnjana Rao
Jul 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ran KafriYitzhak Pilpel
Nov 4, 2006·Developmental Biology·Qiang TuPaola Oliveri
Mar 6, 2007·PLoS Computational Biology·David TalaveraXavier de la Cruz
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael L TressAlfonso Valencia
Apr 13, 2007·Development·Weiguo ShuEdward E Morrisey
Sep 6, 2008·Development Genes and Evolution·Jr-Kai YuSebastian M Shimeld
Feb 28, 2009·Nature Protocols·Lawrence A Kelley, Michael J E Sternberg

❮ Previous
Next ❯

Citations

Jun 22, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Constance Scharff, Jana Petri
Jun 26, 2014·PloS One·Ezequiel MendozaBjörn Brembs
Nov 26, 2014·Annual Review of Genetics·Mi-Jeong YooDouglas E Soltis
Nov 14, 2012·Molecular and Cellular Neurosciences·Mindy R WaiteDonna M Martin
May 20, 2011·Current Opinion in Neurobiology·Wolfgang Enard
Jul 28, 2013·International Reviews of Immunology·Veerle Fleskens, Ruben van Boxtel
Dec 12, 2012·Current Opinion in Neurobiology·Sarah A Graham, Simon E Fisher
Apr 22, 2014·Behavioural Brain Research·Kristy J LawtonDavid L Deitcher
May 24, 2014·Science·Shamik DasGuptaGero Miesenböck
Mar 12, 2011·Behavioural Processes·Björn Brembs
Dec 21, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen J BushAraxi O Urrutia
Mar 5, 2016·PloS One·Michael P DenyerAdrian J Shepherd
Mar 4, 2017·Genetics and Molecular Biology·Lucas Henriques ViscardiMaria Cátira Bortolini
Jul 27, 2017·Biological Reviews of the Cambridge Philosophical Society·Viktor MüllerEörs Szathmáry
Feb 13, 2019·PloS One·Anna Castells-NobauAnnette Schenck
Jul 6, 2014·EvoDevo·Jens H FritzenwankerChristopher J Lowe
May 3, 2012·Médecine sciences : M/S·Mathieu Gabut
Jul 25, 2021·Nucleic Acids Research·Laura Martinez GomezMichael L Tress

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Fluorescence-activated cell sorting
FACS
dissection

Software Mentioned

PAUP
MODELTEST
Ensembl
PYMOL
coot
PHYRE
SWISS
MrBayes
MODEL

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Related Papers

Molecular Biology and Evolution
Claire LarrouxBernard M Degnan
Nucleic Acids Research
Paul FlicekStephen M J Searle
American Journal of Medical Genetics. Part a
Julie GauthierGuy A Rouleau
© 2021 Meta ULC. All rights reserved