Jul 28, 2018

Alternative splicing in cardiomyopathy

Biophysical Reviews
A Beqqali

Abstract

Alternative splicing is an important mechanism used by the cell to generate greater transcriptomic and proteomic diversity from the genome. In the heart, alternative splicing is increasingly being recognised as an important layer of post-transcriptional gene regulation. Driven by rapidly evolving technologies in next-generation sequencing, alternative splicing has emerged as a crucial process governing complex biological processes during cardiac development and disease. The recent identification of several cardiac splice factors, such as RNA-binding motif protein 20 and 24, not only provided important insight into the mechanisms underlying alternative splicing but also revealed how these splicing factors impact functional properties of the heart. Here, we review our current knowledge of alternative splicing in the heart, with a particular focus on the factors controlling cardiac alternative splicing and their role in cardiomyopathies and subsequent heart failure.

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Mentioned in this Paper

Genome
Transcription, Genetic
RBM20 gene
Cardiomyopathies
Proteomics
Massively-Parallel Sequencing
Nuclear mRNA Cis Splicing, via Spliceosome
Cardiac Development
RNA Splicing
Heart

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