Alternative splicing may be responsible for heterogeneity of thyroglobulin structure

Biochimie
L MerckenG Vassart

Abstract

During the cloning of the bovine thyroglobulin cDNA, the restriction map of one of the recombinant plasmids was in disagreement with that of the full-length double-stranded thyroglobulin cDNA. When compared to the bovine Tg mRNA sequence, this cDNA clone exhibits a 333-nucleotide deletion which corresponds precisely to 2 exons of the Tg gene. It is thus likely that alternative processing of the premessenger RNA is at the origin of the deletion. The presence of giant introns in the vicinity of the dispensable exons may also reflect some error level in the splicing mechanism. Together with previous results the alternative splicing described in this study indicates that alternative processing of the Tg transcripts may be at the origin of thyroglobulin isoforms.

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Citations

Feb 1, 1991·Cellular and Molecular Neurobiology·A ChatonnetO Jbilo
Mar 1, 1992·Molecular and Cellular Endocrinology·H M TargovnikG Vassart
Jun 1, 1993·Molecular and Cellular Endocrinology·P N Graves, T F Davies
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Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Manjula Gupta, Su-Ynn Chia
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Jul 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carina M Rivolta, Héctor M Targovnik
Jan 23, 2010·Molecular and Cellular Endocrinology·Héctor M TargovnikCarina M Rivolta
Sep 2, 2008·Expert Review of Anticancer Therapy·German F Barbosa, Mira Milas
Oct 19, 1999·Thyroid : Official Journal of the American Thyroid Association·F M MendiveH M Targovnik
Feb 1, 1989·Biochimie·Y MalthièryS Lissitzky

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