Alternative splicing of Cav2 genes and their functional significance

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Shuji Kaneko

Abstract

Alternative splicing is one of the most pharmacologically and physiologically significant mechanisms for the functional diversity of the mammalian genomes. Here I review recent results on the diversity of the Ca(v)2 subclass of voltage-dependent Ca(2+) channel gene in neurons. Although the entire picture of alternative splicing is not yet understood, emerging evidences suggest the Ca(v)2 isoforms permit optimization of Ca(2+) signaling in different regions of the brain with specific pharmacological ligands.

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Citations

Nov 16, 2007·The European Journal of Neuroscience·Kathryn S RichardsKurt Bommert

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