Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific

Frontiers in Neurology
Cheryl Dykstra-AielloBoryana Stamova

Abstract

Genome-wide association studies have identified putative ischemic stroke risk genes, yet, their expression after stroke is unexplored in spite of growing interest in elucidating their specific role and identifying candidate genes for stroke treatment. Thus, we took an exploratory approach to investigate sexual dimorphism, alternative splicing, and etiology in putative risk gene expression in blood following cardioembolic, atherosclerotic large vessel disease and small vessel disease/lacunar causes of ischemic stroke in each sex compared to controls. Whole transcriptome arrays assessed 71 putative stroke/vascular risk factor genes for blood RNA expression at gene-, exon-, and alternative splicing-levels. Male (n = 122) and female (n = 123) stroke and control volunteers from three university medical centers were matched for race, age, vascular risk factors, and blood draw time since stroke onset. Exclusion criteria included: previous stroke, drug abuse, subarachnoid or intracerebral hemorrhage, hemorrhagic transformation, infection, dialysis, cancer, hematological abnormalities, thrombolytics, anticoagulants or immunosuppressants. Significant differential gene expression (fold change > |1.2|, p < 0.05, partial correlation > |0.4|...Continue Reading

References

Jan 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yang TangFrank R Sharp
Nov 4, 2006·Stroke; a Journal of Cerebral Circulation·Marie Josee E van RijnMonique M B Breteler
Aug 30, 2007·Nature Reviews. Genetics·Guey-Shin Wang, Thomas A Cooper
May 7, 2008·Hypertension·Mohammad Hadi ZafarmandMichiel L Bots
May 28, 2008·Experimental Gerontology·S TrompetUNKNOWN PROSPER Group
Aug 30, 2008·Lancet Neurology·Mathew J ReevesLynda Lisabeth
Nov 11, 2008·Biochimica Et Biophysica Acta·Jamal TaziStefan Stamm
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Tobias FreilingerMartin Dichgans
Apr 17, 2009·The New England Journal of Medicine·M Arfan IkramPhilip A Wolf
Mar 3, 2010·Neurology·N ShobhaUNKNOWN Investigators of the Registry of the Canadian Stroke Network
Apr 23, 2010·The New England Journal of Medicine·UNKNOWN International Stroke Genetics Consortium, UNKNOWN Wellcome Trust Case-Control Consortium 2
Dec 4, 2010·Stroke; a Journal of Cerebral Circulation·James RonaldGail P Jarvik
Dec 25, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yingfang TianFrank R Sharp
Nov 5, 2011·Stroke; a Journal of Cerebral Circulation·Boryana StamovaFrank R Sharp
Dec 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yingfang TianFrank R Sharp
Jan 5, 2012·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jun 30, 2012·Stroke; a Journal of Cerebral Circulation·Sandra OlssonChristina Jern
Sep 4, 2012·Nature Genetics·Elizabeth G HollidayUNKNOWN Wellcome Trust Case Control Consortium 2
Jun 13, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Claire L Gibson
Nov 23, 2013·Stroke; a Journal of Cerebral Circulation·Martin DichgansUNKNOWN International Stroke Genetics Consortium
Feb 8, 2014·Stroke; a Journal of Cerebral Circulation·Cheryl BushnellUNKNOWN Council for High Blood Pressure Research
Feb 11, 2014·Journal of Psychiatric Research·Christopher OldmeadowRodney J Scott
Oct 21, 2014·Journal of Stroke·Arne Lindgren
Oct 8, 2015·Stroke; a Journal of Cerebral Circulation·Matthew TraylorHugh S Markus
Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Claire L Gibson, Luke Attwood
Dec 29, 2015·Lancet Neurology·UNKNOWN NINDS Stroke Genetics Network (SiGN), UNKNOWN International Stroke Genetics Consortium (ISGC)
Jan 1, 2016·Neurology·Stephen R WilliamsUNKNOWN METASTROKE The Genomics and Randomized Trials Network GARNET Collaborative Research Group
Mar 5, 2016·Neurology·Rainer MalikUNKNOWN NINDS Stroke Genetics Network (SiGN)
May 7, 2016·Journal of the American Heart Association·Jessica K PaulusDavid M Kent
Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Cheryl Dykstra-AielloFrank R Sharp
Nov 15, 2016·JAMA Neurology·Michiel H F PoorthuisCatharina J M Klijn
Mar 2, 2017·Genes·Marc Suñé-PouCarlos Suñé
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jul 16, 2019·Circulation. Genomic and Precision Medicine·Matthew TraylorUNKNOWN NINDS Stroke Genetics Network (SiGN) and International Stroke Genetics Consortium (ISGC)

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Citations

Aug 7, 2021·Neurochemistry International·Diandra RuizAshutosh Dharap

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Datasets Mentioned

BETA
DQ925669

Methods Mentioned

BETA
blood draw
blood collection

Software Mentioned

Affymetrix
Partek ANCOVA
Partek® Genomics Suite®

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