Alternative Splicing of Transcription Factors Genes in Muscle Physiology and Pathology

Genes
Carol Imbriano, Susanna Molinari

Abstract

Skeletal muscle formation is a multi-step process that is governed by complex networks of transcription factors. The regulation of their functions is in turn multifaceted, including several mechanisms, among them alternative splicing (AS) plays a primary role. On the other hand, altered AS has a role in the pathogenesis of numerous muscular pathologies. Despite these premises, the causal role played by the altered splicing pattern of transcripts encoding myogenic transcription factors in neuromuscular diseases has been neglected so far. In this review, we systematically investigate what has been described about the AS patterns of transcription factors both in the physiology of the skeletal muscle formation process and in neuromuscular diseases, in the hope that this may be useful in re-evaluating the potential role of altered splicing of transcription factors in such diseases.

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Citations

May 18, 2019·Cell Death & Disease·Soma TripathiJohn C McDermott
Mar 28, 2020·Cells·Debora LibettiRoberto Mantovani
Jul 28, 2020·International Journal of Molecular Sciences·Katarzyna Taylor, Krzysztof Sobczak
Feb 20, 2020·Seminars in Cell & Developmental Biology·Elena NikonovaMaria L Spletter

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Methods Mentioned

BETA
acetylate
nuclear translocation
sumoylation
Antisense Oligonucleotides

Software Mentioned

MYOD

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Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

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