Alternative Stimulation Intensities for Mapping Cortical Motor Area with Navigated TMS

Brain Topography
Elisa Kallioniemi, Petro Julkunen

Abstract

Navigated transcranial magnetic stimulation (nTMS) is becoming a popular tool in pre-operative mapping of functional motor areas. The stimulation intensities used in the mapping are commonly suprathreshold intensities with respect to the patient's resting motor threshold (rMT). There is no consensus on which suprathreshold intensity should be used nor on the optimal criteria for selecting the appropriate stimulation intensity (SI). In this study, the left motor cortices of 12 right-handed volunteers (8 males, age 24-61 years) were mapped using motor evoked potentials with an SI of 110 and 120 % of rMT and with an upper threshold (UT) estimated by the Mills-Nithi algorithm. The UT was significantly lower than 120 % of rMT (p < 0.001), while no significant difference was observed between UT and 110 % of rMT (p = 0.112). The representation sizes followed a similar trend, i.e. areas computed based on UT (5.9 cm(2)) and 110 % of rMT (5.0 cm(2)) being smaller than that of 120 % of rMT (8.8 cm(2)) (p ≤ 0.001). There was no difference in representation sizes between 110 % of rMT and UT. The variance in representation size was found to be significantly lower with UT compared to 120 % of rMT (p = 0.048, uncorrected), while there was no d...Continue Reading

References

Oct 1, 1987·Brain : a Journal of Neurology·S C Gandevia, J C Rothwell
Dec 1, 1993·Electroencephalography and Clinical Neurophysiology·L KiersJ Fang
Apr 1, 1994·Electroencephalography and Clinical Neurophysiology·P MortifeeA Eisen
Jan 1, 1997·Brain : a Journal of Neurology·T A YousryP Winkler
Nov 18, 1997·Electroencephalography and Clinical Neurophysiology·M C Ridding, J C Rothwell
Sep 19, 1998·Electroencephalography and Clinical Neurophysiology·G W ThickbroomF L Mastaglia
Aug 24, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·F A KozelM S George
May 5, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B BoroojerdiL G Cohen
Jul 5, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Valérie DelvauxAlain Maertens de Noordhout
Dec 18, 2003·Supplements to Clinical Neurophysiology·Friedemann Awiszus
Jul 21, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Steven L WolfPaul Weiss
Aug 6, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gary W ThickbroomFrank L Mastaglia
May 14, 2005·Neurophysiologie clinique = Clinical neurophysiology·V K KimiskidisK R Mills
Nov 5, 2005·Stroke; a Journal of Cerebral Circulation·Joachim LiepertCornelius Weiller
Mar 15, 2006·Neurophysiologie clinique = Clinical neurophysiology·C TranulisA Galinovski
Mar 28, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M P MalcolmL J Gonzalez Rothi
Jan 22, 2008·The International Journal of Neuroscience·Scott C Livingston, Christopher D Ingersoll
Nov 11, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Laura SäisänenMervi Könönen
Nov 26, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tim WagnerAntoni Valero-Cabre
Mar 17, 2010·Neurophysiologie clinique = Clinical neurophysiology·J Ruohonen, J Karhu
Oct 5, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Petro JulkunenJari Karhu
Jun 6, 2012·Neuropsychiatric Disease and Treatment·Wellingson S PaivaManoel J Teixeira
Oct 23, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B I SilbertG W Thickbroom
Feb 26, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Angel V PeterchevSarah H Lisanby
Dec 18, 2013·Physics in Medicine and Biology·Ilkka LaaksoYoshikazu Ugawa
Apr 15, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elisa KallioniemiPetro Julkunen
Feb 15, 2015·Brain Stimulation·Jaakko O NieminenRisto J Ilmoniemi

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Citations

May 28, 2016·Neurophysiologie clinique = Clinical neurophysiology·Jean-Pascal Lefaucheur, Thomas Picht
Jan 4, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L S PetroL Muckli
Jul 20, 2017·Brain Topography·Minna PitkänenRisto J Ilmoniemi
Aug 14, 2020·Journal of Neuroscience Methods·Jusa ReijonenPetro Julkunen
Sep 8, 2021·Frontiers in Neuroscience·Rachel E SondergaardElizabeth G Condliffe

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