Alternative Th17 and CD4+ CD25+ FoxP3+ cell frequencies increase and correlate with worse cardiac function in Chagas cardiomyopathy

Scandinavian Journal of Immunology
M S AlmeidaC N L de Morais

Abstract

Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4+CD25+FoxP3+cells, classic Th17 cells, alternative Th17 cells and IL-17+B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4+CD25+FoxP3+, CD4+CD25highFoxP3+, CD4+IL-17+IFN-γ-and CD4+IL-17+IFN-γ+cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4+CD25+FoxP3+and CD4+IL-17+IFN-γ-Th17 cells, this relationship was not observed ...Continue Reading

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Citations

Oct 27, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Francielle Beltrão PereiraCristiane Alves da Silva Menezes
Dec 4, 2020·Translational Psychiatry·Eduardo Duarte-SilvaChristina Alves Peixoto
Jan 29, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·María Carolina Amezcua VeselyEva Virginia Acosta Rodríguez

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