PMID: 8581372Oct 1, 1995Paper

Alternative triggering molecules and single chain bispecific antibodies

Journal of Hematotherapy
D M SegalI Kurucz

Abstract

Although T cell receptors and Fc receptors are the best known cytotoxic triggering molecules, a number of adhesion molecules recently have been identified as alternative triggering molecules. We discuss how CD44, an adhesion molecule found on all leukocytes and many other cell types, becomes a triggering molecule on NK cells following stimulation with IL-2. We also describe a genetically engineered single chain bispecific antibody, produced in mammalian cells and in bacteria, that is capable of redirecting lysis in the nanogram per milliliter range.

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A SethP S Nagarkatti
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·U D Staerz, M J Bevan
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J S HustonR Crea
Jan 1, 1987·European Journal of Immunology·A Lanzavecchia, D Scheidegger
Oct 21, 1988·Science·R E BirdM Whitlow
Aug 1, 1993·Current Opinion in Biotechnology·P Holliger, G Winter
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P HolligerG Winter
Jan 1, 1993·International Reviews of Immunology·J S HustonH Oppermann

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Citations

Apr 1, 1997·Current Opinion in Immunology·M S HaydenJ A Ledbetter
Aug 23, 2002·Neoplasia : an International Journal for Oncology Research·Stuart W FriedrichRakesh K Jain
Apr 28, 2004·Trends in Biotechnology·Peter KuferPatrick A Baeuerle
Jan 11, 2017·MAbs·Ulrich Brinkmann, Roland E Kontermann

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